Version 5.4
Mus musculus Gene: Vdac2
Summary
InnateDB Gene IDBG-137547.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vdac2
Gene Name voltage-dependent anion channel 2
Synonyms mVDAC2; mVDAC6; Vdac6
Species Mus musculus
Ensembl Gene ENSMUSG00000021771
Encoded Proteins
IDBP-137549
voltage-dependent anion channel 2
IDBP-541308
voltage-dependent anion channel 2
IDBP-535996
voltage-dependent anion channel 2
IDBP-623885
voltage-dependent anion channel 2
IDBP-623886
voltage-dependent anion channel 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165637:
This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:21831269-21845879
Strand Forward strand
Band A3
Transcripts
ENSMUST00000022293 ENSMUSP00000022293
ENSMUST00000153320 ENSMUSP00000115560
ENSMUST00000152562 ENSMUSP00000123032
ENSMUST00000147715
ENSMUST00000132364
ENSMUST00000130224
ENSMUST00000142084
ENSMUST00000173456 ENSMUSP00000134023
ENSMUST00000172727 ENSMUSP00000133525
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 51 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0008308 voltage-gated anion channel activity
GO:0015288 porin activity
Biological Process
GO:0006820 anion transport
GO:0032272 negative regulation of protein polymerization
GO:0044070 regulation of anion transport
GO:0055085 transmembrane transport
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0042645 mitochondrial nucleoid
GO:0046930 pore complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000165637
View Gene Order
ENSBTAG00000012975
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04020
Calcium signaling pathway pathway
mmu05012
Parkinson's disease pathway
mmu05016
Huntington's disease pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04020
Calcium signaling pathway pathway
hsa05012
Parkinson's disease pathway
hsa05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.262327 Mm.400502 Mm.468163 Mm.472889
RefSeq NM_011695
OMIM
CCDS CCDS26867
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca