Version 5.4
Bos taurus Gene: VDAC2
Summary
InnateDB Gene IDBG-630714.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VDAC2
Gene Name Voltage-dependent anion-selective channel protein 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012975
Encoded Proteins
IDBP-682195
Voltage-dependent anion-selective channel protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165637:
This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 28:31154552-31168822
Strand Forward strand
Band
Transcripts
ENSBTAT00000017251 ENSBTAP00000017251
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.
Predicted by orthology
Total 52 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0008308 voltage-gated anion channel activity
GO:0015288 porin activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006820 anion transport
GO:0032272 negative regulation of protein polymerization
GO:0044070 regulation of anion transport
GO:0055085 transmembrane transport
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042645 mitochondrial nucleoid
GO:0046930 pore complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000165637
View Gene Order
ENSMUSG00000021771
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04020
Calcium signaling pathway pathway
hsa05012
Parkinson's disease pathway
hsa05016
Huntington's disease pathway
mmu04020
Calcium signaling pathway pathway
mmu05012
Parkinson's disease pathway
mmu05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt P68002
TrEMBL
UniProt Splice Variant
Entrez Gene 282120
UniGene Bt.97408
RefSeq NM_174486 XM_005226327 XM_005226328 XM_005226329
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF268465 AJ288914 BC102904 BT021018
GenPept AAF80102 AAI02905 AAX09035 CAB94711
RNA Seq Atlas 282120

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca