InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Vim

Summary

InnateDB Gene

IDBG-137864.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vim

Gene Name

vimentin

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026728

Encoded Proteins

IDBP-137866

vimentin

IDBP-535135

vimentin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000026025:
This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:13573927-13582826

Strand

Forward strand

Band

Transcripts

ENSMUST00000028062	ENSMUSP00000028062
ENSMUST00000141365	ENSMUSP00000114742
ENSMUST00000155605
ENSMUST00000148248

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 189 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	47 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	189 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0003725	double-stranded RNA binding
GO:0005198	structural molecule activity
GO:0005200	structural constituent of cytoskeleton
GO:0005212	structural constituent of eye lens
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0042802	identical protein binding
GO:0097110	scaffold protein binding

Biological Process

GO:0010628	positive regulation of gene expression
GO:0010977	negative regulation of neuron projection development
GO:0014002	astrocyte development
GO:0045103	intermediate filament-based process
GO:0045109	intermediate filament organization
GO:0060020	Bergmann glial cell differentiation
GO:0070307	lens fiber cell development

Cellular Component

GO:0005737	cytoplasm
GO:0005777	peroxisome
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005882	intermediate filament
GO:0005886	plasma membrane
GO:0031252	cell leading edge
GO:0042995	cell projection
GO:0043005	neuron projection
GO:0045098	type III intermediate filament
GO:0045111	intermediate filament cytoskeleton
GO:0070062	extracellular vesicular exosome