Mus musculus Gene: Vim
Summary
InnateDB Gene IDBG-137864.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vim
Gene Name vimentin
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000026728
Encoded Proteins
vimentin
vimentin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000026025:
This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:13573927-13582826
Strand Forward strand
Band A1
Transcripts
ENSMUST00000028062 ENSMUSP00000028062
ENSMUST00000141365 ENSMUSP00000114742
ENSMUST00000155605
ENSMUST00000148248
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 189 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 47 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 189 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0003725 double-stranded RNA binding
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005212 structural constituent of eye lens
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0042802 identical protein binding
GO:0097110 scaffold protein binding
Biological Process
GO:0010628 positive regulation of gene expression
GO:0010977 negative regulation of neuron projection development
GO:0014002 astrocyte development
GO:0045103 intermediate filament-based process
GO:0045109 intermediate filament organization
GO:0060020 Bergmann glial cell differentiation
GO:0070307 lens fiber cell development
Cellular Component
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005882 intermediate filament
GO:0005886 plasma membrane
GO:0031252 cell leading edge
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0045098 type III intermediate filament
GO:0045111 intermediate filament cytoskeleton
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Apoptosis pathway
Striated Muscle Contraction pathway
Apoptotic cleavage of cellular proteins pathway
Muscle contraction pathway
Caspase-mediated cleavage of cytoskeletal proteins pathway
Apoptotic execution phase pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Alpha6Beta4Integrin pathway
EGFR1 pathway
REACTOME
Apoptotic execution phase pathway
Apoptosis pathway
Apoptotic cleavage of cellular proteins pathway
Caspase-mediated cleavage of cytoskeletal proteins pathway
Muscle contraction pathway
Striated Muscle Contraction pathway
Apoptotic cleavage of cellular proteins pathway
Muscle contraction pathway
Caspase-mediated cleavage of cytoskeletal proteins pathway
Apoptotic execution phase pathway
Striated Muscle Contraction pathway
Apoptosis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Caspase Cascade in Apoptosis
Aurora B signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.268000 Mm.400595 Mm.402398
RefSeq NM_011701
OMIM
CCDS CCDS15696
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas