Mus musculus Gene: Rad21
Summary
InnateDB Gene IDBG-139998.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rad21
Gene Name RAD21 homolog (S. pombe)
Synonyms mKIAA0078; SCC1;
Species Mus musculus
Ensembl Gene ENSMUSG00000022314
Encoded Proteins
RAD21 homolog (S. pombe)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] RAD21 is part of the cohesin complex which is the cellular machinery involved in sister chromatid cohesion and that which requires access to the nucleosomal DNA to perform its function in chromosome segregation.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164754:
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:51962605-51991760
Strand Reverse strand
Band C
Transcripts
ENSMUST00000022927 ENSMUSP00000022927
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 218 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 28 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 218 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006281 DNA repair
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0071168 protein localization to chromatin
Cellular Component
GO:0000228 nuclear chromosome
GO:0000775 chromosome, centromeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0008278 cohesin complex
GO:0016020 membrane
GO:0034991 nuclear meiotic cohesin complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Mus musculus biological processes pathway
Cell Cycle, Mitotic pathway
Separation of Sister Chromatids pathway
Resolution of Sister Chromatid Cohesion pathway
Meiotic synapsis pathway
Cell Cycle pathway
M Phase pathway
Mitotic Telophase/Cytokinesis pathway
Mitotic Metaphase and Anaphase pathway
Mitotic Prometaphase pathway
Meiotic Synapsis pathway
Cohesin Loading onto Chromatin pathway
Establishment of Sister Chromatid Cohesion pathway
Meiosis pathway
Mitotic Anaphase pathway
S Phase pathway
KEGG
Cell cycle pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Mitotic Telophase/Cytokinesis pathway
Meiotic synapsis pathway
S Phase pathway
Separation of Sister Chromatids pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
M Phase pathway
Mitotic Anaphase pathway
Cohesin Loading onto Chromatin pathway
Cell Cycle, Mitotic pathway
Establishment of Sister Chromatid Cohesion pathway
Meiosis pathway
Resolution of Sister Chromatid Cohesion pathway
Mitotic Metaphase and Anaphase pathway
S Phase pathway
Cohesin Loading onto Chromatin pathway
Meiotic synapsis pathway
Mitotic Telophase/Cytokinesis pathway
M Phase pathway
Separation of Sister Chromatids pathway
Meiosis pathway
Mitotic Metaphase and Anaphase pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
Cell Cycle pathway
Establishment of Sister Chromatid Cohesion pathway
Resolution of Sister Chromatid Cohesion pathway
Mitotic Prometaphase pathway
KEGG
Cell cycle pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q61550
TrEMBL Q3UTE4
UniProt Splice Variant
Entrez Gene 19357
UniGene Mm.182628 Mm.470496
RefSeq NM_009009 XM_006520644 XM_006520645
OMIM
CCDS CCDS27463
HPRD
IMGT
MGI ID MGI:108016
MGI Symbol Rad21
EMBL AF332085 AF332086 AK004746 AK139492 AK163992 BC043032 D49429 X98293
GenPept AAH43032 AAK56113 AAK56114 BAA08408 BAB23527 BAE24036 BAE37576 CAA66939
RNA Seq Atlas 19357