Mus musculus Gene: Lama2
Summary
InnateDB Gene IDBG-140720.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lama2
Gene Name laminin, alpha 2
Synonyms 5830440B04; dy; mer; merosin; mKIAA4087;
Species Mus musculus
Ensembl Gene ENSMUSG00000019899
Encoded Proteins
laminin, alpha 2
laminin, alpha 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196569:
Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:26980036-27619758
Strand Reverse strand
Band A4
Transcripts
ENSMUST00000092639 ENSMUSP00000090304
ENSMUST00000186279
ENSMUST00000189575 ENSMUSP00000140716
ENSMUST00000185839
ENSMUST00000186965
ENSMUST00000188963
ENSMUST00000187535
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007411 axon guidance
GO:0016192 vesicle-mediated transport
GO:0022011 myelination in peripheral nervous system
GO:0030155 regulation of cell adhesion
GO:0030198 extracellular matrix organization
GO:0030334 regulation of cell migration
GO:0032224 positive regulation of synaptic transmission, cholinergic
GO:0045995 regulation of embryonic development
Cellular Component
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005605 basal lamina
GO:0005606 laminin-1 complex
GO:0016020 membrane
GO:0042383 sarcolemma
GO:0043197 dendritic spine
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Extracellular matrix organization pathway
Laminin interactions pathway
Non-integrin membrane-ECM interactions pathway
KEGG
Focal adhesion pathway
ECM-receptor interaction pathway
Toxoplasmosis pathway
Amoebiasis pathway
Pathways in cancer pathway
Small cell lung cancer pathway
Hypertrophic cardiomyopathy (HCM) pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Dilated cardiomyopathy pathway
Viral myocarditis pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Alpha6Beta4Integrin pathway
REACTOME
Extracellular matrix organization pathway
ECM proteoglycans pathway
Non-integrin membrane-ECM interactions pathway
Laminin interactions pathway
KEGG
Focal adhesion pathway
ECM-receptor interaction pathway
Toxoplasmosis pathway
Amoebiasis pathway
Pathways in cancer pathway
Small cell lung cancer pathway
Hypertrophic cardiomyopathy (HCM) pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Dilated cardiomyopathy pathway
Viral myocarditis pathway
INOH
PID BIOCARTA
Agrin in postsynaptic differentiation [Biocarta view]
PID NCI
Beta1 integrin cell surface interactions
Alpha6 beta4 integrin-ligand interactions
Cross-References
SwissProt Q60675
TrEMBL Q8C9J2
UniProt Splice Variant
Entrez Gene 16773
UniGene Mm.256087
RefSeq NM_008481 XM_006512566
OMIM
CCDS CCDS48526
HPRD
IMGT
MGI ID MGI:99912
MGI Symbol Lama2
EMBL AC101709 AC152982 AC153800 AC155942 AC167232 AC171406 AK042011 S75315 U12147 X69869
GenPept AAB33573 AAC52165 BAC31130 CAA49502
RNA Seq Atlas 16773