Version 5.4
Mus musculus Gene: Plk4
Summary
InnateDB Gene IDBG-141445.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plk4
Gene Name polo-like kinase 4
Synonyms 1700028H20; AI385771; Sak; Stk18
Species Mus musculus
Ensembl Gene ENSMUSG00000025758
Encoded Proteins
IDBP-141447
polo-like kinase 4 (Drosophila)
IDBP-624360
polo-like kinase 4 (Drosophila)
IDBP-624363
polo-like kinase 4 (Drosophila)
IDBP-624366
polo-like kinase 4 (Drosophila)
IDBP-624367
polo-like kinase 4 (Drosophila)
IDBP-624370
polo-like kinase 4 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to the nucleolus during G2, to centrosomes during G2/M, and to the cleavage furrow during cytokinesis. It is required for progression through mitosis, cell survival, and embryonic development. The mouse genome contains a pseudogene similar to this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:40800019-40816883
Strand Forward strand
Band B
Transcripts
ENSMUST00000026858 ENSMUSP00000026858
ENSMUST00000168363
ENSMUST00000170825 ENSMUSP00000128916
ENSMUST00000168287 ENSMUSP00000129134
ENSMUST00000167556 ENSMUSP00000126945
ENSMUST00000169566 ENSMUSP00000133225
ENSMUST00000166936
ENSMUST00000171538 ENSMUSP00000130134
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042802 identical protein binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007099 centriole replication
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0046601 positive regulation of centriole replication
GO:0060707 trophoblast giant cell differentiation
GO:0098535 de novo centriole assembly
Cellular Component
GO:0005730 nucleolus
GO:0005813 centrosome
GO:0005814 centriole
GO:0032154 cleavage furrow
GO:0098536 deuterosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000142731
View Gene Order
ENSBTAG00000039552
Not yet available
Pathways
NETPATH
REACTOME
REACT_245720
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_240530
G2/M Transition pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_243078
Loss of Nlp from mitotic centrosomes pathway
REACT_188804
Cell Cycle pathway
REACT_246508
Mitotic G2-G2/M phases pathway
REACT_244487
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_196635
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_253753
Centrosome maturation pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_15364
Loss of Nlp from mitotic centrosomes pathway
REACT_15451
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_115566
Cell Cycle pathway
REACT_15479
Centrosome maturation pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_223914
G2/M Transition pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_205006
Loss of Nlp from mitotic centrosomes pathway
REACT_217933
Mitotic G2-G2/M phases pathway
REACT_214934
Cell Cycle pathway
REACT_214350
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_224118
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_215812
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_210400
Centrosome maturation pathway
KEGG
INOH
PID NCI
plk_pathway
Polo-like kinase signaling events in the cell cycle
plk2_4pathway
PLK2 and PLK4 events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.3794 Mm.394685 Mm.468332 Mm.487878
RefSeq NM_011495 NM_173169 XM_006500768 XM_006500769
OMIM
CCDS CCDS17328 CCDS57210
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca