InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rnf14

Summary

InnateDB Gene

IDBG-141607.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf14

Gene Name

ring finger protein 14

Synonyms

2310075C09Rik; 2610005D23Rik; AA986456; AU041447; D18Ertd188e; D7Bwg0165e; Triad2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000060450

Encoded Proteins

IDBP-141609

ring finger protein 14

IDBP-622278

ring finger protein 14

IDBP-622285

ring finger protein 14

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000013561:
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:38296635-38317847

Strand

Forward strand

Band

Transcripts

ENSMUST00000072376	ENSMUSP00000072212
ENSMUST00000171461	ENSMUSP00000126205
ENSMUST00000170811	ENSMUSP00000133070

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019787	small conjugating protein ligase activity
GO:0050681	androgen receptor binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008152	metabolic process
GO:0032355	response to estradiol
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060765	regulation of androgen receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000013561

View Gene Order

ENSBTAG00000005249

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_2

AndrogenReceptor pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

G3XA54

UniProt Splice Variant

Entrez Gene

56736

UniGene

RefSeq

NM_001164622 XM_006526128 NM_001164621 NM_020012 XM_006526121 XM_006526122 XM_006526123 XM_006526124 XM_006526125 XM_006526126 XM_006526127

OMIM

CCDS

CCDS50261 CCDS29200

HPRD

IMGT

MGI ID

MGI:1929668

MGI Symbol

Rnf14

EMBL

AC152450 CH466528

GenPept

EDL10088

RNA Seq Atlas

56736