Version 5.4
Bos taurus Gene: RNF14
Summary
InnateDB Gene IDBG-646125.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF14
Gene Name E3 ubiquitin-protein ligase RNF14
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005249
Encoded Proteins
IDBP-698900
E3 ubiquitin-protein ligase RNF14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000013561:
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:54717280-54735688
Strand Forward strand
Band
Transcripts
ENSBTAT00000006908 ENSBTAP00000006908
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019787 small conjugating protein ligase activity
GO:0046872 metal ion binding
GO:0050681 androgen receptor binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0032355 response to estradiol
GO:0060765 regulation of androgen receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000013561
View Gene Order
ENSMUSG00000060450
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A2VDU5
UniProt Splice Variant
Entrez Gene 540274
UniGene Bt.6818
RefSeq NM_001081540 XM_005209474 XM_005209475 XM_005209476 XM_005209477 XM_005209478 XM_005209479 XM_005209480
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133406 DAAA02020447
GenPept AAI33407
RNA Seq Atlas 540274

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca