Version 5.4
Homo sapiens Gene: CLU
Summary
InnateDB Gene IDBG-14287.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLU
Gene Name clusterin
Synonyms APO-J; APOJ; CLI; CLU1; CLU2; KUB1; NA1/NA2; SGP-2; SGP2; SP-40; TRPM-2; TRPM2;
Species Homo sapiens
Ensembl Gene ENSG00000120885
Encoded Proteins
IDBP-14289
clusterin
IDBP-294744
clusterin
IDBP-484941
clusterin
IDBP-476654
clusterin
IDBP-482194
clusterin
IDBP-479064
clusterin
IDBP-478963
clusterin
IDBP-477242
clusterin
IDBP-476088
clusterin
IDBP-476146
clusterin
IDBP-474995
clusterin
IDBP-481570
clusterin
IDBP-480122
clusterin
IDBP-586675
clusterin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:27596917-27615031
Strand Reverse strand
Band p21.1
Transcripts
ENST00000316403 ENSP00000315130
ENST00000405140 ENSP00000385419
ENST00000523500 ENSP00000429620
ENST00000522299
ENST00000521770 ENSP00000428033
ENST00000522098 ENSP00000430821
ENST00000522502
ENST00000523589 ENSP00000431070
ENST00000520796 ENSP00000429336
ENST00000519742 ENSP00000431026
ENST00000520491 ENSP00000429881
ENST00000522413 ENSP00000428779
ENST00000518050
ENST00000519472 ENSP00000427868
ENST00000523396 ENSP00000428526
ENST00000522238 ENSP00000429087
ENST00000560566 ENSP00000453247
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 96 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 96 [view]
Protein-Protein 92 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0051787 misfolded protein binding
Biological Process
GO:0000902 cell morphogenesis
GO:0001774 microglial cell activation
GO:0001836 release of cytochrome c from mitochondria
GO:0002576 platelet degranulation
GO:0006629 lipid metabolic process
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0007596 blood coagulation
GO:0008219 cell death
GO:0009615 response to virus
GO:0017038 protein import
GO:0030168 platelet activation
GO:0032286 central nervous system myelin maintenance
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032463 negative regulation of protein homooligomerization
GO:0032760 positive regulation of tumor necrosis factor production
GO:0043065 positive regulation of apoptotic process
GO:0043691 reverse cholesterol transport
GO:0045087 innate immune response
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0050821 protein stabilization
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051131 chaperone-mediated protein complex assembly
GO:0051788 response to misfolded protein
GO:0061077 chaperone-mediated protein folding
GO:0061518 microglial cell proliferation
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900221 regulation of beta-amyloid clearance
GO:1901214 regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1902004 positive regulation of beta-amyloid formation
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902430 negative regulation of beta-amyloid formation
GO:1902847 regulation of neuronal signal transduction
GO:1902949 positive regulation of tau-protein kinase activity
GO:1902998 positive regulation of neurofibrillary tangle assembly
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0031012 extracellular matrix
GO:0031093 platelet alpha granule lumen
GO:0031966 mitochondrial membrane
GO:0034366 spherical high-density lipoprotein particle
GO:0042583 chromaffin granule
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
GO:0097418 neurofibrillary tangle
GO:0097440 apical dendrite
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000022037
View Gene Order
Ortholuge
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
ENSBTAG00000005574
Not yet available
Ortholuge
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
REACT_318
Platelet degranulation pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
myc_represspathway
Validated targets of C-MYC transcriptional repression
Cross-References
SwissProt P10909
TrEMBL B4DW11 E5RG36 E5RGB0 E5RH61 E5RJD6 E5RJZ5 E7ERK6 Q6LDQ3 Q8IWL5 Q8IWM0
UniProt Splice Variant
Entrez Gene 1191
UniGene Hs.619313
RefSeq NM_001831 XM_006716284
HUGO HGNC:2095
OMIM 185430
CCDS CCDS47832
HPRD 01706
IMGT
EMBL AF311103 AK093399 AK301324 AK313870 AY172563 AY184486 AY341244 AY513288 BC010514 BC019588 BU150467 BX648414 CR599675 J02908 L00974 M25915 M26639 M63376 M63377 M63378 M63379 M64722 M74816 X14723
GenPept AAA35692 AAA36609 AAA51765 AAA60321 AAA60567 AAB06507 AAB06508 AAH10514 AAH19588 AAN78322 AAN87347 AAP88927 AAT08041 BAG36598 BAG52708 BAG62873 CAA32847 CAI45990
RNA Seq Atlas 1191

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca