InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CLU

Summary

InnateDB Gene

IDBG-629759.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLU

Gene Name

Clusterin Clusterin beta chain Clusterin alpha chain

Synonyms

gpIII

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005574

Encoded Proteins

IDBP-681173

ClusterinClusterin beta chainClusterin alpha chain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that is similar to the human clusterin protein, a secreted chaperone that can also be found in the cell cytosol under certain stress conditions. The human protein has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders.[provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:11043941-11061301

Strand

Forward strand

Band

Transcripts

ENSBTAT00000007324

ENSBTAP00000007324

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	62 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0031625	ubiquitin protein ligase binding
GO:0051787	misfolded protein binding

Biological Process

GO:0008219	cell death
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032463	negative regulation of protein homooligomerization
GO:0043065	positive regulation of apoptotic process
GO:0050821	protein stabilization
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051788	response to misfolded protein
GO:0061077	chaperone-mediated protein folding
GO:0097193	intrinsic apoptotic signaling pathway
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0016020	membrane
GO:0031012	extracellular matrix
GO:0031410	cytoplasmic vesicle
GO:0031966	mitochondrial membrane
GO:0034366	spherical high-density lipoprotein particle
GO:0042583	chromaffin granule
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm