Homo sapiens Gene: POLD2
Summary
InnateDB Gene IDBG-14295.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLD2
Gene Name polymerase (DNA directed), delta 2, accessory subunit
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000106628
Encoded Proteins
polymerase (DNA directed), delta 2, regulatory subunit 50kDa
polymerase (DNA directed), delta 2, regulatory subunit 50kDa
polymerase (DNA directed), delta 2, regulatory subunit 50kDa
polymerase (DNA directed), delta 2, regulatory subunit 50kDa
polymerase (DNA directed), delta 2, regulatory subunit 50kDa
polymerase (DNA directed), delta 2, regulatory subunit 50kDa
polymerase (DNA directed), delta 2, regulatory subunit 50kDa
polymerase (DNA directed), delta 2, regulatory subunit 50kDa
polymerase (DNA directed), delta 2, accessory subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]
This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3\' to 5\' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:44114681-44124358
Strand Reverse strand
Band p13
Transcripts
ENST00000223361 ENSP00000223361
ENST00000406581 ENSP00000386105
ENST00000452185 ENSP00000395231
ENST00000436400 ENSP00000399447
ENST00000436844 ENSP00000416203
ENST00000433715 ENSP00000389816
ENST00000456038 ENSP00000397461
ENST00000418438 ENSP00000406702
ENST00000489883
ENST00000481104
ENST00000463464
ENST00000470867
ENST00000464871
ENST00000461116
ENST00000467469
ENST00000496539
ENST00000481763
ENST00000610533 ENSP00000480186
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0000722 telomere maintenance via recombination
GO:0000723 telomere maintenance
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006284 base-excision repair
GO:0006289 nucleotide-excision repair
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0032201 telomere maintenance via semi-conservative replication
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0043625 delta DNA polymerase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
DNA Replication pathway
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
Polymerase switching on the C-strand of the telomere pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Transcription-coupled NER (TC-NER) pathway
Synthesis of DNA pathway
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
Removal of the Flap Intermediate from the C-strand pathway
Resolution of Abasic Sites (AP sites) pathway
Removal of the Flap Intermediate pathway
S Phase pathway
Chromosome Maintenance pathway
Polymerase switching pathway
Global Genomic NER (GG-NER) pathway
Telomere Maintenance pathway
Removal of DNA patch containing abasic residue pathway
Cell Cycle pathway
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
Base Excision Repair pathway
Processive synthesis on the lagging strand pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
Mismatch Repair pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
Processive synthesis on the C-strand of the telomere pathway
Leading Strand Synthesis pathway
Extension of Telomeres pathway
Lagging Strand Synthesis pathway
Nucleotide Excision Repair pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
DNA Repair pathway
KEGG
Purine metabolism pathway
Pyrimidine metabolism pathway
DNA replication pathway
Base excision repair pathway
Nucleotide excision repair pathway
Mismatch repair pathway
Homologous recombination pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.306791
RefSeq NM_001127218 NM_001256879 NM_006230 XM_006715745
HUGO
OMIM
CCDS CCDS5477 CCDS75586
HPRD 15982
IMGT
EMBL
GenPept
RNA Seq Atlas