Mus musculus Gene: Pold2
Summary
InnateDB Gene IDBG-145597.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pold2
Gene Name polymerase (DNA directed), delta 2, regulatory subunit
Synonyms 50kDa; p50; po1D2;
Species Mus musculus
Ensembl Gene ENSMUSG00000020471
Encoded Proteins
polymerase (DNA directed), delta 2, regulatory subunit
polymerase (DNA directed), delta 2, regulatory subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106628:
This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]
This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3\' to 5\' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:5872180-5878292
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000102922 ENSMUSP00000099986
ENSMUST00000141907
ENSMUST00000153995 ENSMUSP00000122906
ENSMUST00000136714
ENSMUST00000134957
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
Cellular Component
GO:0005634 nucleus
GO:0043625 delta DNA polymerase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Processive synthesis on the lagging strand pathway
Transcription-coupled NER (TC-NER) pathway
Removal of the Flap Intermediate pathway
Cell Cycle, Mitotic pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
Chromosome Maintenance pathway
Synthesis of DNA pathway
DNA strand elongation pathway
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
DNA Replication pathway
Base Excision Repair pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
Global Genomic NER (GG-NER) pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Telomere Maintenance pathway
Cell Cycle pathway
Nucleotide Excision Repair pathway
Removal of the Flap Intermediate from the C-strand pathway
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
DNA Repair pathway
Leading Strand Synthesis pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
Removal of DNA patch containing abasic residue pathway
Mismatch Repair pathway
Extension of Telomeres pathway
Polymerase switching pathway
Processive synthesis on the C-strand of the telomere pathway
Lagging Strand Synthesis pathway
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
Resolution of Abasic Sites (AP sites) pathway
Polymerase switching on the C-strand of the telomere pathway
S Phase pathway
KEGG
Purine metabolism pathway
Pyrimidine metabolism pathway
DNA replication pathway
Base excision repair pathway
Nucleotide excision repair pathway
Mismatch repair pathway
Homologous recombination pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
DNA Replication pathway
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
Polymerase switching on the C-strand of the telomere pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Transcription-coupled NER (TC-NER) pathway
Synthesis of DNA pathway
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
Removal of the Flap Intermediate from the C-strand pathway
Resolution of Abasic Sites (AP sites) pathway
Removal of the Flap Intermediate pathway
S Phase pathway
Chromosome Maintenance pathway
Polymerase switching pathway
Global Genomic NER (GG-NER) pathway
Telomere Maintenance pathway
Removal of DNA patch containing abasic residue pathway
Cell Cycle pathway
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
Base Excision Repair pathway
Processive synthesis on the lagging strand pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
Mismatch Repair pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
Processive synthesis on the C-strand of the telomere pathway
Leading Strand Synthesis pathway
Extension of Telomeres pathway
Lagging Strand Synthesis pathway
Nucleotide Excision Repair pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
DNA Repair pathway
S Phase pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
Extension of Telomeres pathway
Transcription-coupled NER (TC-NER) pathway
Removal of the Flap Intermediate from the C-strand pathway
DNA Replication pathway
Telomere Maintenance pathway
Polymerase switching on the C-strand of the telomere pathway
Leading Strand Synthesis pathway
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
Resolution of Abasic Sites (AP sites) pathway
Removal of the Flap Intermediate pathway
Nucleotide Excision Repair pathway
Cell Cycle, Mitotic pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Global Genomic NER (GG-NER) pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Processive synthesis on the lagging strand pathway
Processive synthesis on the C-strand of the telomere pathway
Synthesis of DNA pathway
Cell Cycle pathway
DNA Repair pathway
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
Lagging Strand Synthesis pathway
Mismatch Repair pathway
Removal of DNA patch containing abasic residue pathway
Base Excision Repair pathway
Chromosome Maintenance pathway
Polymerase switching pathway
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
DNA strand elongation pathway
KEGG
Purine metabolism pathway
Pyrimidine metabolism pathway
DNA replication pathway
Base excision repair pathway
Nucleotide excision repair pathway
Mismatch repair pathway
Homologous recombination pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.35788 Mm.468552
RefSeq NM_008894 XM_006514587
OMIM
CCDS CCDS24407
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas