InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FANCM

Summary

InnateDB Gene

IDBG-5587.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FANCM

Gene Name

Fanconi anemia, complementation group M

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000187790

Encoded Proteins

IDBP-5589

Fanconi anemia, complementation group M

IDBP-600255

Fanconi anemia, complementation group M

IDBP-595993

Fanconi anemia, complementation group M

IDBP-587187

Fanconi anemia, complementation group M

IDBP-595624

Fanconi anemia, complementation group M

IDBP-593092

Fanconi anemia, complementation group M

IDBP-592247

Fanconi anemia, complementation group M

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:45135940-45200890

Strand

Forward strand

Band

q21.2

Transcripts

ENST00000267430	ENSP00000267430
ENST00000556036	ENSP00000450596
ENST00000542564	ENSP00000442493
ENST00000554030
ENST00000556250	ENSP00000452033
ENST00000554809	ENSP00000450632
ENST00000555013
ENST00000557110	ENSP00000451846
ENST00000555484	ENSP00000450797
ENST00000553551

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	39 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0004386	helicase activity
GO:0004518	nuclease activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity

Biological Process

GO:0000712	resolution of meiotic recombination intermediates
GO:0006259	DNA metabolic process
GO:0006281	DNA repair
GO:0031297	replication fork processing
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0043240	Fanconi anaemia nuclear complex
GO:0071821	FANCM-MHF complex

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000055884

View Gene Order

Pathways

NETPATH

REACTOME

REACT_18410

Fanconi Anemia pathway pathway

REACT_216

DNA Repair pathway

KEGG

INOH

PID NCI

fanconi_pathway

Fanconi anemia pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

57697

UniGene

Hs.509229

RefSeq

NM_020937

HUGO

HGNC:23168

OMIM

609644

CCDS

CCDS32070

HPRD

13876

IMGT

EMBL

GenPept

RNA Seq Atlas

57697