InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Chmp2a

Summary

InnateDB Gene

IDBG-144086.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chmp2a

Gene Name

charged multivesicular body protein 2A

Synonyms

1500016L11Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000033916

Encoded Proteins

IDBP-144088

charged multivesicular body protein 2A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130724:
CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:13032006-13034777

Strand

Reverse strand

Band

Transcripts

ENSMUST00000005711

ENSMUSP00000005711

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding

Biological Process

GO:0015031	protein transport
GO:0045184	establishment of protein localization
GO:0050792	regulation of viral process
GO:1902188	positive regulation of viral release from host cell

Cellular Component

GO:0005829	cytosol
GO:0016020	membrane
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000130724

View Gene Order

ENSBTAG00000013882

Not yet available

Pathways

NETPATH

REACTOME

REACT_209837

Membrane Trafficking pathway

REACT_198518

Endosomal Sorting Complex Required For Transport (ESCRT) pathway

KEGG

mmu04144

Endocytosis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_6361

Late Phase of HIV Life Cycle pathway

REACT_27258

Endosomal Sorting Complex Required For Transport (ESCRT) pathway

REACT_6256

HIV Life Cycle pathway

REACT_6185

HIV Infection pathway

REACT_6359

Budding and maturation of HIV virion pathway

REACT_116125

Disease pathway

REACT_11123

Membrane Trafficking pathway

KEGG

hsa04144

Endocytosis pathway

INOH

PID NCI

Cross-References

SwissProt

Q9DB34

TrEMBL

UniProt Splice Variant

Entrez Gene

68953

UniGene

Mm.467385

RefSeq

NM_026885 XM_006540345

OMIM

CCDS

CCDS20824

HPRD

IMGT

MGI ID

MGI:1916203

MGI Symbol

Chmp2a

EMBL

AK005267 BC012230

GenPept

AAH12230 BAB23919

RNA Seq Atlas

68953