Homo sapiens Gene: EDEM1
Summary
InnateDB Gene IDBG-14540.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EDEM1
Gene Name ER degradation enhancer, mannosidase alpha-like 1
Synonyms EDEM;
Species Homo sapiens
Ensembl Gene ENSG00000134109
Encoded Proteins
ER degradation enhancer, mannosidase alpha-like 1
ER degradation enhancer, mannosidase alpha-like 1
ER degradation enhancer, mannosidase alpha-like 1
ER degradation enhancer, mannosidase alpha-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:5187646-5219957
Strand Forward strand
Band p26.1
Transcripts
ENST00000256497 ENSP00000256497
ENST00000434243 ENSP00000393659
ENST00000443790 ENSP00000394615
ENST00000445686 ENSP00000394099
ENST00000465369
ENST00000465187
ENST00000492751
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0051787 misfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0008152 metabolic process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
IRE1alpha activates chaperones pathway
Unfolded Protein Response (UPR) pathway
Calnexin/calreticulin cycle pathway
Post-translational protein modification pathway
XBP1(S) activates chaperone genes pathway
Asparagine N-linked glycosylation pathway
Metabolism of proteins pathway
ER Quality Control Compartment (ERQC) pathway
N-glycan trimming in the ER and Calnexin/Calreticulin cycle pathway
KEGG
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
Er associated degradation (erad) pathway [Biocarta view]
PID NCI
Cross-References
SwissProt Q92611
TrEMBL A0A024R2D5
UniProt Splice Variant
Entrez Gene 9695
UniGene Hs.224616 Hs.596714 Hs.609833 Hs.673002
RefSeq NM_014674 XM_006713424 XM_006713425
HUGO HGNC:18967
OMIM 607673
CCDS CCDS33686
HPRD 09644
IMGT
EMBL AK292643 BC019088 CH471055 D86967
GenPept AAH19088 BAA13203 BAF85332 EAW63925 EAW63926
RNA Seq Atlas 9695