Version 5.4
Mus musculus Gene: Napa
Summary
InnateDB Gene IDBG-145793.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Napa
Gene Name N-ethylmaleimide sensitive fusion protein attachment protein alpha
Synonyms 1500039N14Rik; a-SNAP; AW209189; hyh; RA81; SNAPA; SNARE
Species Mus musculus
Ensembl Gene ENSMUSG00000006024
Encoded Proteins
IDBP-145795
N-ethylmaleimide sensitive fusion protein attachment protein alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105402:
This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded protein plays a role in the completion of membrane fusion by mediating the interaction of N-ethylmaleimide-sensitive factor (NSF) with the vesicle-associated and membrane-associated SNAP receptor (SNARE) complex, and stimulating the ATPase activity of NSF. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:16098458-16117975
Strand Forward strand
Band A2
Transcripts
ENSMUST00000006181 ENSMUSP00000006181
ENSMUST00000127637
ENSMUST00000124563
ENSMUST00000132828
ENSMUST00000139507
ENSMUST00000150208
ENSMUST00000140640
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000149 SNARE binding
GO:0005515 protein binding
GO:0019905 syntaxin binding
Biological Process
GO:0006886 intracellular protein transport
GO:0007420 brain development
GO:0010807 regulation of synaptic vesicle priming
GO:0030182 neuron differentiation
GO:0035249 synaptic transmission, glutamatergic
GO:0035494 SNARE complex disassembly
GO:0045176 apical protein localization
Cellular Component
GO:0016020 membrane
GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105402
View Gene Order
ENSBTAG00000013084
Not yet available
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_232671
Golgi Associated Vesicle Biogenesis pathway
REACT_243409
trans-Golgi Network Vesicle Budding pathway
REACT_234979
Clathrin derived vesicle budding pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.104540
RefSeq NM_025898
OMIM
CCDS CCDS20843
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca