InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NAPA

Summary

InnateDB Gene

IDBG-59588.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NAPA

Gene Name

N-ethylmaleimide-sensitive factor attachment protein, alpha

Synonyms

SNAPA

Species

Homo sapiens

Ensembl Gene

ENSG00000105402

Encoded Proteins

IDBP-59590

N-ethylmaleimide-sensitive factor attachment protein, alpha

IDBP-760944

IDBP-760919

IDBP-763300

IDBP-763579

IDBP-765976

IDBP-765793

IDBP-763368

IDBP-765593

IDBP-760976

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded protein plays a role in the completion of membrane fusion by mediating the interaction of N-ethylmaleimide-sensitive factor (NSF) with the vesicle-associated and membrane-associated SNAP receptor (SNARE) complex, and stimulating the ATPase activity of NSF. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:47487637-47515240

Strand

Reverse strand

Band

q13.33

Transcripts

ENST00000263354	ENSP00000263354
ENST00000594217	ENSP00000472235
ENST00000593905
ENST00000597271
ENST00000597274	ENSP00000470954
ENST00000594288
ENST00000597118	ENSP00000471018
ENST00000594155	ENSP00000471261
ENST00000594001	ENSP00000470654
ENST00000597778
ENST00000602174
ENST00000602082
ENST00000598615	ENSP00000470946
ENST00000595826
ENST00000601927
ENST00000594740
ENST00000595227	ENSP00000471520
ENST00000601208	ENSP00000470665
ENST00000596892
ENST00000597160
ENST00000593785
ENST00000593761	ENSP00000472667

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	36 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005515	protein binding
GO:0019905	syntaxin binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006891	intra-Golgi vesicle-mediated transport
GO:0006892	post-Golgi vesicle-mediated transport
GO:0007420	brain development
GO:0010807	regulation of synaptic vesicle priming
GO:0030182	neuron differentiation
GO:0035249	synaptic transmission, glutamatergic
GO:0035494	SNARE complex disassembly
GO:0045176	apical protein localization
GO:0061024	membrane organization
GO:0061025	membrane fusion

Cellular Component

GO:0005829	cytosol
GO:0016020	membrane
GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000006024

View Gene Order

ENSBTAG00000013084

Not yet available

Pathways

NETPATH

REACTOME

REACT_19400

Golgi Associated Vesicle Biogenesis pathway

REACT_19187

Clathrin derived vesicle budding pathway

REACT_11235

trans-Golgi Network Vesicle Budding pathway

REACT_11123

Membrane Trafficking pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.730799

RefSeq

NM_003827

HUGO

OMIM

CCDS

CCDS12702

HPRD

04447

IMGT

EMBL

GenPept

RNA Seq Atlas