Homo sapiens Gene: NAPA
Summary
InnateDB Gene IDBG-59588.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAPA
Gene Name N-ethylmaleimide-sensitive factor attachment protein, alpha
Synonyms SNAPA;
Species Homo sapiens
Ensembl Gene ENSG00000105402
Encoded Proteins
N-ethylmaleimide-sensitive factor attachment protein, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded protein plays a role in the completion of membrane fusion by mediating the interaction of N-ethylmaleimide-sensitive factor (NSF) with the vesicle-associated and membrane-associated SNAP receptor (SNARE) complex, and stimulating the ATPase activity of NSF. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:47487637-47515240
Strand Reverse strand
Band q13.33
Transcripts
ENST00000263354 ENSP00000263354
ENST00000594217 ENSP00000472235
ENST00000593905
ENST00000597271
ENST00000597274 ENSP00000470954
ENST00000594288
ENST00000597118 ENSP00000471018
ENST00000594155 ENSP00000471261
ENST00000594001 ENSP00000470654
ENST00000597778
ENST00000602174
ENST00000602082
ENST00000598615 ENSP00000470946
ENST00000595826
ENST00000601927
ENST00000594740
ENST00000595227 ENSP00000471520
ENST00000601208 ENSP00000470665
ENST00000596892
ENST00000597160
ENST00000593785
ENST00000593761 ENSP00000472667
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 36 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000149 SNARE binding
GO:0005515 protein binding
GO:0019905 syntaxin binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006891 intra-Golgi vesicle-mediated transport
GO:0006892 post-Golgi vesicle-mediated transport
GO:0007420 brain development
GO:0010807 regulation of synaptic vesicle priming
GO:0030182 neuron differentiation
GO:0035249 synaptic transmission, glutamatergic
GO:0035494 SNARE complex disassembly
GO:0045176 apical protein localization
GO:0061024 membrane organization
GO:0061025 membrane fusion
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
trans-Golgi Network Vesicle Budding pathway
Clathrin derived vesicle budding pathway
Golgi Associated Vesicle Biogenesis pathway
Membrane Trafficking pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.730799
RefSeq NM_003827
HUGO
OMIM
CCDS CCDS12702
HPRD 04447
IMGT
EMBL
GenPept
RNA Seq Atlas