Version 5.4
Mus musculus Gene: Mgat4a
Summary
InnateDB Gene IDBG-146044.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mgat4a
Gene Name mannoside acetylglucosaminyltransferase 4, isoenzyme A
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000026110
Encoded Proteins
IDBP-146046
mannoside acetylglucosaminyltransferase 4, isoenzyme A
IDBP-542166
mannoside acetylglucosaminyltransferase 4, isoenzyme A
IDBP-538746
mannoside acetylglucosaminyltransferase 4, isoenzyme A
IDBP-536219
mannoside acetylglucosaminyltransferase 4, isoenzyme A
IDBP-540526
mannoside acetylglucosaminyltransferase 4, isoenzyme A
IDBP-542165
mannoside acetylglucosaminyltransferase 4, isoenzyme A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071073:
This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:37439340-37541016
Strand Reverse strand
Band B
Transcripts
ENSMUST00000042161 ENSMUSP00000038894
ENSMUST00000151952 ENSMUSP00000114175
ENSMUST00000154819 ENSMUSP00000121181
ENSMUST00000143636 ENSMUSP00000122909
ENSMUST00000149791 ENSMUSP00000115778
ENSMUST00000148047 ENSMUSP00000118692
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
GO:0016758 transferase activity, transferring hexosyl groups
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006486 protein glycosylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000071073
View Gene Order
ENSBTAG00000010388
Not yet available
Pathways
NETPATH
REACTOME
REACT_198565
N-Glycan antennae elongation pathway
REACT_198566
N-glycan antennae elongation in the medial/trans-Golgi pathway
REACT_206143
Transport to the Golgi and subsequent modification pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_237472
Asparagine N-linked glycosylation pathway
KEGG
mmu00510
N-Glycan biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25085
N-Glycan antennae elongation pathway
REACT_25046
Transport to the Golgi and subsequent modification pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_25208
N-glycan antennae elongation in the medial/trans-Golgi pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00510
N-Glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.25861 Mm.443123
RefSeq NM_001290801 NM_173870 XM_006496022 XM_006496023 XM_006496024 XM_006496025 XM_006496026 XM_006496027
OMIM
CCDS CCDS14893 CCDS69882
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca