InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MGAT4A

Summary

InnateDB Gene

IDBG-63060.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MGAT4A

Gene Name

mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A

Synonyms

GnT-4a; GNT-IV; GNT-IVA

Species

Homo sapiens

Ensembl Gene

ENSG00000071073

Encoded Proteins

IDBP-63062

mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A

IDBP-243517

mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A

IDBP-295188

mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A

IDBP-383431

mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A

IDBP-807245

mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:98619106-98731126

Strand

Reverse strand

Band

q11.2

Transcripts

ENST00000264968	ENSP00000264968
ENST00000393487	ENSP00000377127
ENST00000409391	ENSP00000386841
ENST00000414521	ENSP00000404889
ENST00000492163
ENST00000461884
ENST00000484936
ENST00000460768
ENST00000495056	ENSP00000475198

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
GO:0016758	transferase activity, transferring hexosyl groups
GO:0046872	metal ion binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006491	N-glycan processing
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0000139	Golgi membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026110

View Gene Order

ENSBTAG00000010388

Not yet available

Pathways

NETPATH

REACTOME

REACT_25085

N-Glycan antennae elongation pathway

REACT_25046

Transport to the Golgi and subsequent modification pathway

REACT_22426

Asparagine N-linked glycosylation pathway

REACT_22161

Post-translational protein modification pathway

REACT_25208

N-glycan antennae elongation in the medial/trans-Golgi pathway

REACT_17015

Metabolism of proteins pathway

KEGG

hsa00510

N-Glycan biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

U3KPT4

UniProt Splice Variant

Entrez Gene

11320

UniGene

RefSeq

NM_001160154 NM_012214

HUGO

HGNC:7047

OMIM

604623

CCDS

CCDS2036 CCDS54380

HPRD

IMGT

EMBL

AC064860 AC109826

GenPept

RNA Seq Atlas

11320