Version 5.4
Homo sapiens Gene: RBBP8
Summary
InnateDB Gene IDBG-1496.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBBP8
Gene Name retinoblastoma binding protein 8
Synonyms COM1; CTIP; JWDS; RIM; SAE2; SCKL2
Species Homo sapiens
Ensembl Gene ENSG00000101773
Encoded Proteins
IDBP-1498
retinoblastoma binding protein 8
IDBP-1502
retinoblastoma binding protein 8
IDBP-229946
retinoblastoma binding protein 8
IDBP-229948
retinoblastoma binding protein 8
IDBP-229950
retinoblastoma binding protein 8
IDBP-811425
retinoblastoma binding protein 8
IDBP-726548
IDBP-726166
IDBP-725692
IDBP-725544
IDBP-727461
IDBP-727014
IDBP-726970
IDBP-727563
IDBP-725891
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:22798261-23026488
Strand Forward strand
Band q11.2
Transcripts
ENST00000327155 ENSP00000323050
ENST00000360790 ENSP00000354024
ENST00000399725 ENSP00000382630
ENST00000399722 ENSP00000382628
ENST00000399721 ENSP00000382627
ENST00000585177 ENSP00000477396
ENST00000583700 ENSP00000464628
ENST00000583594 ENSP00000463908
ENST00000582354 ENSP00000463738
ENST00000577588 ENSP00000464284
ENST00000581687 ENSP00000463544
ENST00000583057 ENSP00000464691
ENST00000580892
ENST00000579124 ENSP00000462390
ENST00000581819 ENSP00000463439
ENST00000577445 ENSP00000463310
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 65 [view]
Protein-Protein 62 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000014 single-stranded DNA endodeoxyribonuclease activity
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0003684 damaged DNA binding
GO:0005515 protein binding
Biological Process
GO:0000075 cell cycle checkpoint
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000724 double-strand break repair via homologous recombination
GO:0000737 DNA catabolic process, endonucleolytic
GO:0001835 blastocyst hatching
GO:0006281 DNA repair
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007067 mitotic nuclear division
GO:0007126 meiotic nuclear division
GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing
GO:0031572 G2 DNA damage checkpoint
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0017053 transcriptional repressor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041238
View Gene Order
ENSBTAG00000006743
Not yet available
Pathways
NETPATH
REACTOME
REACT_27271
Meiotic recombination pathway
REACT_115566
Cell Cycle pathway
REACT_111183
Meiosis pathway
KEGG
INOH
PID NCI
hes_heypathway
Notch-mediated HES/HEY network
e2f_pathway
E2F transcription factor network
bard1pathway
BARD1 signaling events
atm_pathway
ATM pathway
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL J3KSA4 J3QL93 J3QRM0
UniProt Splice Variant
Entrez Gene 5932
UniGene Hs.546282 Hs.736556
RefSeq NM_002894 NM_203291 NM_203292 XM_005258326 XM_006722519 XM_006722520 XM_006722521 XM_006722522
HUGO HGNC:9891
OMIM 604124
CCDS CCDS11874 CCDS11875
HPRD 04990
IMGT
EMBL AC090912 AC091147 AC106033
GenPept
RNA Seq Atlas 5932

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca