Mus musculus Gene: Sst
Summary
InnateDB Gene IDBG-149849.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sst
Gene Name somatostatin
Synonyms Smst; SOM; SRIF; SS;
Species Mus musculus
Ensembl Gene ENSMUSG00000004366
Encoded Proteins
somatostatin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157005:
The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:23889581-23890844
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000004480 ENSMUSP00000004480
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
Biological Process
GO:0001101 response to acid
GO:0006972 hyperosmotic response
GO:0009408 response to heat
GO:0010243 response to organonitrogen compound
GO:0030334 regulation of cell migration
GO:0042493 response to drug
GO:0043200 response to amino acid
GO:0048545 response to steroid hormone
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0043025 neuronal cell body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
GPCR downstream signaling pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
GPCR ligand binding pathway
Peptide ligand-binding receptors pathway
G alpha (i) signalling events pathway
Signal Transduction pathway
KEGG
Gastric acid secretion pathway
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Gastric acid secretion pathway
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P60041
TrEMBL Q545V6
UniProt Splice Variant
Entrez Gene 20604
UniGene
RefSeq NM_009215
OMIM
CCDS CCDS28080
HPRD
IMGT
MGI ID MGI:98326
MGI Symbol Sst
EMBL AK003014 BC010770 CH466521 X51468
GenPept AAH10770 BAB22513 CAA35831 EDK97673
RNA Seq Atlas 20604