Version 5.4
Homo sapiens Gene: SST
Summary
InnateDB Gene IDBG-69330.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SST
Gene Name somatostatin
Synonyms SMST
Species Homo sapiens
Ensembl Gene ENSG00000157005
Encoded Proteins
IDBP-69332
somatostatin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:187668906-187670399
Strand Reverse strand
Band q27.3
Transcripts
ENST00000287641 ENSP00000287641
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
Biological Process
GO:0001101 response to acid
GO:0006972 hyperosmotic response
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007268 synaptic transmission
GO:0007584 response to nutrient
GO:0007586 digestion
GO:0008285 negative regulation of cell proliferation
GO:0008628 hormone-mediated apoptotic signaling pathway
GO:0009408 response to heat
GO:0010243 response to organonitrogen compound
GO:0030334 regulation of cell migration
GO:0042493 response to drug
GO:0043200 response to amino acid
GO:0048545 response to steroid hormone
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004366
View Gene Order
ENSBTAG00000017312
Not yet available
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04971
Gastric acid secretion pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001048
HUGO
OMIM
CCDS CCDS3288
HPRD 08920
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca