Version 5.4
Mus musculus Gene: Trp63
Summary
InnateDB Gene IDBG-150133.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trp63
Gene Name transformation related protein 63
Synonyms AI462811; Ket; P51/P63; P63; P73l; Tp63; Trp53rp1
Species Mus musculus
Ensembl Gene ENSMUSG00000022510
Encoded Proteins
IDBP-150135
transformation related protein 63
IDBP-150137
transformation related protein 63
IDBP-249919
transformation related protein 63
IDBP-249921
transformation related protein 63
IDBP-249923
transformation related protein 63
IDBP-249925
transformation related protein 63
IDBP-249927
transformation related protein 63
IDBP-249929
transformation related protein 63
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21367858
Trp63 is a crucial regulator downstream of Tlr3 in Poly(I:C)-induced signalling. Trp63 activates the signalling of both extrinsic and intrinsic apoptosis pathways in endothelial cells through death receptors and mitochondria.
InnateDB Annotation from Orthologs
Summary
PMID 21367858
[Homo sapiens] TP63 is a crucial regulator downstream of TLR3 in Poly(I:C)-induced signalling. TP63 activates the signalling of both extrinsic and intrinsic apoptosis pathways in endothelial cells through death receptors and mitochondria.
Entrez Gene
Summary This gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include tumor proteins p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways, including direct and indirect protein interactions. This results in mutual regulation of target gene promoters. Tumor protein p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Both alternative splicing and the use of alternative promoters result in multiple transcript variants encoding different protein isoforms.[provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:25683763-25892102
Strand Forward strand
Band B1
Transcripts
ENSMUST00000065523 ENSMUSP00000067005
ENSMUST00000040231 ENSMUSP00000038117
ENSMUST00000115310 ENSMUSP00000110965
ENSMUST00000115308 ENSMUSP00000110963
ENSMUST00000115307 ENSMUSP00000110962
ENSMUST00000115306 ENSMUSP00000110961
ENSMUST00000115305 ENSMUSP00000110960
ENSMUST00000115304 ENSMUSP00000110959
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 116 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 9 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 116 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000989 transcription factor binding transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0042802 identical protein binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
GO:0050699 WW domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001302 replicative cell aging
GO:0001501 skeletal system development
GO:0001736 establishment of planar polarity
GO:0001738 morphogenesis of a polarized epithelium
GO:0001942 hair follicle development
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002064 epithelial cell development
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0007389 pattern specification process
GO:0007499 ectoderm and mesoderm interaction
GO:0007569 cell aging
GO:0008544 epidermis development
GO:0009887 organ morphogenesis
GO:0009954 proximal/distal pattern formation
GO:0010165 response to X-ray
GO:0010259 multicellular organismal aging
GO:0010332 response to gamma radiation
GO:0010481 epidermal cell division
GO:0010482 regulation of epidermal cell division
GO:0010838 positive regulation of keratinocyte proliferation
GO:0030154 cell differentiation
GO:0030216 keratinocyte differentiation
GO:0030326 embryonic limb morphogenesis
GO:0030850 prostate gland development
GO:0030855 epithelial cell differentiation
GO:0030859 polarized epithelial cell differentiation
GO:0031069 hair follicle morphogenesis
GO:0031571 mitotic G1 DNA damage checkpoint
GO:0034644 cellular response to UV
GO:0036342 post-anal tail morphogenesis
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043066 negative regulation of apoptotic process
GO:0043523 regulation of neuron apoptotic process
GO:0043589 skin morphogenesis
GO:0043616 keratinocyte proliferation
GO:0045087 innate immune response (InnateDB)
GO:0045617 negative regulation of keratinocyte differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048485 sympathetic nervous system development
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048745 smooth muscle tissue development
GO:0048807 female genitalia morphogenesis
GO:0051262 protein tetramerization
GO:0051289 protein homotetramerization
GO:0051402 neuron apoptotic process
GO:0060157 urinary bladder development
GO:0060197 cloacal septation
GO:0060513 prostatic bud formation
GO:0060529 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0061436 establishment of skin barrier
GO:1902808 positive regulation of cell cycle G1/S phase transition
GO:2000271 positive regulation of fibroblast apoptotic process
GO:2000381 negative regulation of mesoderm development
GO:2000773 negative regulation of cellular senescence
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005791 rough endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0030425 dendrite
GO:0043005 neuron projection
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000073282
View Gene Order
ENSBTAG00000015460
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
p73pathway
p73 transcription factor network
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
tap63pathway
Validated transcriptional targets of TAp63 isoforms
p63pathway
p63 transcription factor network
Cross-References
SwissProt
TrEMBL D3Z7K2
UniProt Splice Variant
Entrez Gene 22061
UniGene Mm.20894 Mm.398545
RefSeq NM_001127259 NM_001127260 NM_001127261 NM_001127262 NM_001127263 NM_001127264 NM_001127265 NM_011641 XM_006522000 XM_006522001 XM_006522002 XM_006522003
OMIM
CCDS CCDS28085 CCDS49808 CCDS49809 CCDS49810 CCDS49811 CCDS49812
HPRD
IMGT
MGI ID MGI:1330810
MGI Symbol Trp63
EMBL AC109213 AC113020
GenPept
RNA Seq Atlas 22061

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca