Version 5.4
Bos taurus Gene: TP63
Summary
InnateDB Gene IDBG-634533.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TP63
Gene Name tumor protein 63
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015460
Encoded Proteins
IDBP-686316
tumor protein p63
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 21367858
[Homo sapiens] TP63 is a crucial regulator downstream of TLR3 in Poly(I:C)-induced signalling. TP63 activates the signalling of both extrinsic and intrinsic apoptosis pathways in endothelial cells through death receptors and mitochondria.
PMID 21367858
[Mus musculus] Trp63 is a crucial regulator downstream of Tlr3 in Poly(I:C)-induced signalling. Trp63 activates the signalling of both extrinsic and intrinsic apoptosis pathways in endothelial cells through death receptors and mitochondria.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073282:
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:78012414-78283420
Strand Reverse strand
Band
Transcripts
ENSBTAT00000020544 ENSBTAP00000020544
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 114 interaction(s) predicted by orthology.
Predicted by orthology
Total 114 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000989 transcription factor binding transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0050699 WW domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0001736 establishment of planar polarity
GO:0001738 morphogenesis of a polarized epithelium
GO:0001942 hair follicle development
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002064 epithelial cell development
GO:0006338 chromatin remodeling
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007389 pattern specification process
GO:0007499 ectoderm and mesoderm interaction
GO:0007569 cell aging
GO:0008544 epidermis development
GO:0009887 organ morphogenesis
GO:0009954 proximal/distal pattern formation
GO:0010259 multicellular organismal aging
GO:0010481 epidermal cell division
GO:0010482 regulation of epidermal cell division
GO:0010838 positive regulation of keratinocyte proliferation
GO:0030154 cell differentiation
GO:0030216 keratinocyte differentiation
GO:0030326 embryonic limb morphogenesis
GO:0030850 prostate gland development
GO:0030855 epithelial cell differentiation
GO:0030859 polarized epithelial cell differentiation
GO:0031069 hair follicle morphogenesis
GO:0036342 post-anal tail morphogenesis
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043066 negative regulation of apoptotic process
GO:0043589 skin morphogenesis
GO:0043616 keratinocyte proliferation
GO:0045617 negative regulation of keratinocyte differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048485 sympathetic nervous system development
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048745 smooth muscle tissue development
GO:0048807 female genitalia morphogenesis
GO:0051262 protein tetramerization
GO:0051289 protein homotetramerization
GO:0051402 neuron apoptotic process
GO:0060157 urinary bladder development
GO:0060197 cloacal septation
GO:0060513 prostatic bud formation
GO:0060529 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0061436 establishment of skin barrier
GO:1902808 positive regulation of cell cycle G1/S phase transition
GO:2000271 positive regulation of fibroblast apoptotic process
GO:2000381 negative regulation of mesoderm development
GO:2000773 negative regulation of cellular senescence
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000073282
View Gene Order
ENSMUSG00000022510
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
p73pathway
p73 transcription factor network
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
tap63pathway
Validated transcriptional targets of TAp63 isoforms
p63pathway
p63 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.24897
RefSeq NM_001191337 XM_005201548 XM_005201549 XM_005201550
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca