Version 5.4
Mus musculus Gene: Asah1
Summary
InnateDB Gene IDBG-151209.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Asah1
Gene Name N-acylsphingosine amidohydrolase 1
Synonyms 2310081N20Rik; AC; Asah
Species Mus musculus
Ensembl Gene ENSMUSG00000031591
Encoded Proteins
IDBP-151211
N-acylsphingosine amidohydrolase 1
IDBP-260311
N-acylsphingosine amidohydrolase 1
IDBP-533852
N-acylsphingosine amidohydrolase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104763:
This gene encodes a heterodimeric protein consisting of a nonglycosylated alpha subunit and a glycosylated beta subunit that is cleaved to the mature enzyme posttranslationally. The encoded protein catalyzes the synthesis and degradation of ceramide into sphingosine and fatty acid. Mutations in this gene have been associated with a lysosomal storage disorder known as Farber disease. Multiple transcript variants encoding several distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:41340197-41374773
Strand Reverse strand
Band A4
Transcripts
ENSMUST00000034000 ENSMUSP00000034000
ENSMUST00000110417 ENSMUSP00000106047
ENSMUST00000126561
ENSMUST00000131796
ENSMUST00000143057 ENSMUSP00000117362
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0017040 ceramidase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008152 metabolic process
GO:0010033 response to organic substance
GO:0030324 lung development
Cellular Component
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104763
View Gene Order
ENSBTAG00000011257
Not yet available
Pathways
NETPATH
REACTOME
REACT_199008
Glycosphingolipid metabolism pathway
REACT_188937
Metabolism pathway
REACT_245163
Sphingolipid metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
KEGG
mmu00600
Sphingolipid metabolism pathway
mmu04142
Lysosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_116105
Glycosphingolipid metabolism pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_204575
Glycosphingolipid metabolism pathway
REACT_222556
Sphingolipid metabolism pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
KEGG
hsa00600
Sphingolipid metabolism pathway
hsa04142
Lysosome pathway
INOH
PID NCI
ceramide_pathway
Ceramide signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.22547 Mm.392205
RefSeq NM_019734
OMIM
CCDS CCDS22262
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca