Mus musculus Gene: Asah1
Summary
InnateDB Gene IDBG-151209.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Asah1
Gene Name N-acylsphingosine amidohydrolase 1
Synonyms 2310081N20Rik; AC; Asah;
Species Mus musculus
Ensembl Gene ENSMUSG00000031591
Encoded Proteins
N-acylsphingosine amidohydrolase 1
N-acylsphingosine amidohydrolase 1
N-acylsphingosine amidohydrolase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104763:
This gene encodes a heterodimeric protein consisting of a nonglycosylated alpha subunit and a glycosylated beta subunit that is cleaved to the mature enzyme posttranslationally. The encoded protein catalyzes the synthesis and degradation of ceramide into sphingosine and fatty acid. Mutations in this gene have been associated with a lysosomal storage disorder known as Farber disease. Multiple transcript variants encoding several distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:41340197-41374773
Strand Reverse strand
Band A4
Transcripts
ENSMUST00000034000 ENSMUSP00000034000
ENSMUST00000110417 ENSMUSP00000106047
ENSMUST00000126561
ENSMUST00000131796
ENSMUST00000143057 ENSMUSP00000117362
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0017040 ceramidase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008152 metabolic process
GO:0010033 response to organic substance
GO:0030324 lung development
Cellular Component
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Glycosphingolipid metabolism pathway
Metabolism pathway
Sphingolipid metabolism pathway
Metabolism of lipids and lipoproteins pathway
KEGG
Sphingolipid metabolism pathway
Lysosome pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Sphingolipid metabolism pathway
Metabolism of lipids and lipoproteins pathway
Glycosphingolipid metabolism pathway
Metabolism pathway
Glycosphingolipid metabolism pathway
Sphingolipid metabolism pathway
Metabolism of lipids and lipoproteins pathway
Metabolism pathway
KEGG
Sphingolipid metabolism pathway
Lysosome pathway
INOH
PID BIOCARTA
Phospholipids as signalling intermediaries [Biocarta view]
PID NCI
Ceramide signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.22547 Mm.392205
RefSeq NM_019734
OMIM
CCDS CCDS22262
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas