Version 5.4
Homo sapiens Gene: ZMIZ2
Summary
InnateDB Gene IDBG-15128.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZMIZ2
Gene Name zinc finger, MIZ-type containing 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000122515
Encoded Proteins
IDBP-15130
zinc finger, MIZ-type containing 2
IDBP-15132
zinc finger, MIZ-type containing 2
IDBP-374348
zinc finger, MIZ-type containing 2
IDBP-374350
zinc finger, MIZ-type containing 2
IDBP-374357
zinc finger, MIZ-type containing 2
IDBP-374359
zinc finger, MIZ-type containing 2
IDBP-374362
zinc finger, MIZ-type containing 2
IDBP-810355
zinc finger, MIZ-type containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).[supplied by OMIM, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:44748581-44769881
Strand Forward strand
Band p13
Transcripts
ENST00000309315 ENSP00000311778
ENST00000265346 ENSP00000265346
ENST00000413916 ENSP00000409648
ENST00000457123 ENSP00000415501
ENST00000416856 ENSP00000406820
ENST00000441627 ENSP00000414723
ENST00000433667 ENSP00000396601
ENST00000492001
ENST00000478045
ENST00000463056
ENST00000480964
ENST00000492558
ENST00000463931
ENST00000482322
ENST00000615423 ENSP00000483853
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0043596 nuclear replication fork
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041164
View Gene Order
ENSBTAG00000011997
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID NCI
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001300959 NM_031449 NM_174929 XM_005249869 XM_005249872 XM_005249873 XM_005249874
HUGO
OMIM
CCDS CCDS43576 CCDS43577 CCDS75591
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca