Mus musculus Gene: Atp6v1d
Summary
InnateDB Gene IDBG-152073.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atp6v1d
Gene Name ATPase, H+ transporting, lysosomal V1 subunit D
Synonyms 1110004P10Rik; Atp6m; VATD; Vma8;
Species Mus musculus
Ensembl Gene ENSMUSG00000021114
Encoded Proteins
ATPase, H+ transporting, lysosomal V1 subunit D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100554:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:78842989-78861638
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000021536 ENSMUSP00000021536
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
Biological Process
GO:0015992 proton transport
GO:0042384 cilium assembly
GO:0055085 transmembrane transport
GO:0061512 protein localization to cilium
Cellular Component
GO:0005765 lysosomal membrane
GO:0005813 centrosome
GO:0005929 cilium
GO:0016020 membrane
GO:0016471 vacuolar proton-transporting V-type ATPase complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Disease pathway
Signaling by Insulin receptor pathway
Transferrin endocytosis and recycling pathway
Phagosomal maturation (early endosomal stage) pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Iron uptake and transport pathway
Transmembrane transport of small molecules pathway
Insulin receptor recycling pathway
Signal Transduction pathway
KEGG
Oxidative phosphorylation pathway
Phagosome pathway
Collecting duct acid secretion pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Iron uptake and transport pathway
Insulin receptor recycling pathway
Signal Transduction pathway
Transferrin endocytosis and recycling pathway
Phagosomal maturation (early endosomal stage) pathway
Signaling by Insulin receptor pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Disease pathway
KEGG
Oxidative phosphorylation pathway
Phagosome pathway
Collecting duct acid secretion pathway
Vibrio cholerae infection pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P57746
TrEMBL Q3U861 Q9CTI8
UniProt Splice Variant
Entrez Gene 73834
UniGene Mm.311549
RefSeq NM_023721
OMIM
CCDS CCDS26002
HPRD
IMGT
MGI ID MGI:1921084
MGI Symbol Atp6v1d
EMBL AF298810 AK003446 AK147910 AK152367 AK165761 BC033457 CH466590
GenPept AAG30225 AAH33457 BAB22795 BAE28222 BAE31157 BAE38369 EDL02626
RNA Seq Atlas 73834