Homo sapiens Gene: ATP6V1D
Summary
InnateDB Gene IDBG-9840.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP6V1D
Gene Name ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000100554
Encoded Proteins
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:67294371-67360265
Strand Reverse strand
Band q23.3
Transcripts
ENST00000216442 ENSP00000216442
ENST00000554087 ENSP00000451167
ENST00000553974
ENST00000553408 ENSP00000450834
ENST00000555625 ENSP00000451564
ENST00000555474 ENSP00000450885
ENST00000555431 ENSP00000450841
ENST00000554236 ENSP00000452192
ENST00000555723 ENSP00000452029
ENST00000556058 ENSP00000451422
ENST00000555335
ENST00000553687 ENSP00000452492
ENST00000555012 ENSP00000451031
ENST00000557244
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 22 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
Biological Process
GO:0006879 cellular iron ion homeostasis
GO:0008286 insulin receptor signaling pathway
GO:0015992 proton transport
GO:0033572 transferrin transport
GO:0042384 cilium assembly
GO:0051701 interaction with host
GO:0055085 transmembrane transport
GO:0061512 protein localization to cilium
GO:0090382 phagosome maturation
Cellular Component
GO:0005765 lysosomal membrane
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005929 cilium
GO:0016020 membrane
GO:0016471 vacuolar proton-transporting V-type ATPase complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Iron uptake and transport pathway
Insulin receptor recycling pathway
Signal Transduction pathway
Transferrin endocytosis and recycling pathway
Phagosomal maturation (early endosomal stage) pathway
Signaling by Insulin receptor pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Disease pathway
KEGG
Oxidative phosphorylation pathway
Phagosome pathway
Collecting duct acid secretion pathway
Vibrio cholerae infection pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.670912 Hs.735253
RefSeq NM_015994
HUGO
OMIM
CCDS CCDS9780
HPRD 16524
IMGT
EMBL
GenPept
RNA Seq Atlas