Mus musculus Gene: Bdh1
Summary
InnateDB Gene IDBG-152901.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bdh1
Gene Name 3-hydroxybutyrate dehydrogenase, type 1
Synonyms 2310032J20Rik; AI327223; Bdh;
Species Mus musculus
Ensembl Gene ENSMUSG00000046598
Encoded Proteins
3-hydroxybutyrate dehydrogenase, type 1
3-hydroxybutyrate dehydrogenase, type 1
3-hydroxybutyrate dehydrogenase, type 1
3-hydroxybutyrate dehydrogenase, type 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161267:
This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:31422280-31458901
Strand Forward strand
Band B2
Transcripts
ENSMUST00000089759 ENSMUSP00000087192
ENSMUST00000115227 ENSMUSP00000110882
ENSMUST00000115226 ENSMUSP00000110881
ENSMUST00000128286
ENSMUST00000149039 ENSMUSP00000119164
ENSMUST00000126825
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003858 3-hydroxybutyrate dehydrogenase activity
GO:0005543 phospholipid binding
GO:0016491 oxidoreductase activity
Biological Process
GO:0001889 liver development
GO:0007420 brain development
GO:0007584 response to nutrient
GO:0008152 metabolic process
GO:0009636 response to toxic substance
GO:0009725 response to hormone
GO:0032355 response to estradiol
GO:0032868 response to insulin
GO:0042493 response to drug
GO:0042594 response to starvation
GO:0045471 response to ethanol
GO:0046686 response to cadmium ion
GO:0051412 response to corticosterone
GO:0055114 oxidation-reduction process
GO:0060416 response to growth hormone
GO:0060612 adipose tissue development
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Synthesis of Ketone Bodies pathway
Ketone body metabolism pathway
Utilization of Ketone Bodies pathway
KEGG
Synthesis and degradation of ketone bodies pathway
Butanoate metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TCR pathway
REACTOME
Metabolism of lipids and lipoproteins pathway
Ketone body metabolism pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Utilization of Ketone Bodies pathway
Synthesis of Ketone Bodies pathway
Synthesis of Ketone Bodies pathway
Utilization of Ketone Bodies pathway
Ketone body metabolism pathway
Metabolism of lipids and lipoproteins pathway
Metabolism pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
KEGG
Synthesis and degradation of ketone bodies pathway
Butanoate metabolism pathway
INOH
Butanoate metabolism pathway
PID BIOCARTA
PID NCI
FOXA2 and FOXA3 transcription factor networks
Cross-References
SwissProt
TrEMBL D3Z2Y8
UniProt Splice Variant
Entrez Gene 71911
UniGene
RefSeq NM_175177 NM_001122683
OMIM
CCDS CCDS28106
HPRD
IMGT
MGI ID MGI:1919161
MGI Symbol Bdh1
EMBL AC125371
GenPept
RNA Seq Atlas 71911