Homo sapiens Gene: BDH1
Summary
InnateDB Gene IDBG-71705.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BDH1
Gene Name 3-hydroxybutyrate dehydrogenase, type 1
Synonyms BDH; SDR9C1;
Species Homo sapiens
Ensembl Gene ENSG00000161267
Encoded Proteins
3-hydroxybutyrate dehydrogenase, type 1
3-hydroxybutyrate dehydrogenase, type 1
3-hydroxybutyrate dehydrogenase, type 1
3-hydroxybutyrate dehydrogenase, type 1
3-hydroxybutyrate dehydrogenase, type 1
3-hydroxybutyrate dehydrogenase, type 1
3-hydroxybutyrate dehydrogenase, type 1
3-hydroxybutyrate dehydrogenase, type 1
3-hydroxybutyrate dehydrogenase, type 1
3-hydroxybutyrate dehydrogenase, type 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:197509783-197573323
Strand Reverse strand
Band q29
Transcripts
ENST00000358186 ENSP00000350914
ENST00000392379 ENSP00000376184
ENST00000392378 ENSP00000376183
ENST00000441275 ENSP00000411014
ENST00000446746 ENSP00000387648
ENST00000455876 ENSP00000408016
ENST00000445160 ENSP00000405462
ENST00000434143 ENSP00000408685
ENST00000432819 ENSP00000409849
ENST00000431056 ENSP00000396149
ENST00000479425
ENST00000477015
ENST00000483920
ENST00000495285
ENST00000468710
ENST00000492681
ENST00000476764
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003858 3-hydroxybutyrate dehydrogenase activity
GO:0005543 phospholipid binding
GO:0016491 oxidoreductase activity
Biological Process
GO:0001889 liver development
GO:0007420 brain development
GO:0007584 response to nutrient
GO:0008152 metabolic process
GO:0009636 response to toxic substance
GO:0009725 response to hormone
GO:0032355 response to estradiol
GO:0032868 response to insulin
GO:0042493 response to drug
GO:0042594 response to starvation
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045471 response to ethanol
GO:0046686 response to cadmium ion
GO:0046950 cellular ketone body metabolic process
GO:0046951 ketone body biosynthetic process
GO:0046952 ketone body catabolic process
GO:0051412 response to corticosterone
GO:0055114 oxidation-reduction process
GO:0060416 response to growth hormone
GO:0060612 adipose tissue development
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TCR pathway
REACTOME
Metabolism of lipids and lipoproteins pathway
Ketone body metabolism pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Utilization of Ketone Bodies pathway
Synthesis of Ketone Bodies pathway
KEGG
Synthesis and degradation of ketone bodies pathway
Butanoate metabolism pathway
INOH
Butanoate metabolism pathway
PID BIOCARTA
PID NCI
FOXA2 and FOXA3 transcription factor networks
Cross-References
SwissProt
TrEMBL C9JB83 C9JEB9 C9JQ90
UniProt Splice Variant
Entrez Gene 622
UniGene Hs.274539
RefSeq NM_004051 NM_203314 NM_203315 XM_005269352
HUGO HGNC:1027
OMIM 603063
CCDS CCDS3328
HPRD 04344
IMGT
EMBL AC128709 AC132008
GenPept
RNA Seq Atlas 622