InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nlrp5

Summary

InnateDB Gene

IDBG-153886.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nlrp5

Gene Name

NLR family, pyrin domain containing 5

Synonyms

Mater; Nalp5; Op1; PAN11

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015721

Encoded Proteins

IDBP-153888

NLR family, pyrin domain containing 5

IDBP-153890

NLR family, pyrin domain containing 5

IDBP-264532

NLR family, pyrin domain containing 5

IDBP-536944

NLR family, pyrin domain containing 5

IDBP-540032

NLR family, pyrin domain containing 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18648497

[Homo sapiens] NLRP5 is a part of the NLRP (Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing) family, has a role in apoptosis and inflammation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171487:
The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). Expression of this gene is restricted to the oocyte. A mouse gene that encodes a maternal oocyte protein, similar to this encoded protein, is required for normal early embryogenesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:23385889-23441922

Strand

Forward strand

Band

Transcripts

ENSMUST00000086341	ENSMUSP00000083524
ENSMUST00000015866	ENSMUSP00000015866
ENSMUST00000108441	ENSMUSP00000104080
ENSMUST00000139661	ENSMUSP00000118638
ENSMUST00000133237	ENSMUSP00000122007

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0001701	in utero embryonic development
GO:0007566	embryo implantation
GO:0009566	fertilization
GO:0009887	organ morphogenesis
GO:0031647	regulation of protein stability
GO:0034613	cellular protein localization
GO:0043487	regulation of RNA stability
GO:0043623	cellular protein complex assembly
GO:0070997	neuron death

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005938	cell cortex
GO:0043234	protein complex
GO:0045179	apical cortex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000171487

View Gene Order

ENSBTAG00000013247

Not yet available

Cross-References

SwissProt

Q9R1M5

TrEMBL

UniProt Splice Variant

Entrez Gene

23968

UniGene

Mm.333653 Mm.420946

RefSeq

NM_011860 NM_001039143

OMIM

CCDS

CCDS20930 CCDS20929

HPRD

IMGT

MGI ID

MGI:1345193

MGI Symbol

Nlrp5

EMBL

AF074018 AF143559 AF143560 AF143561 AF143562 AF143563 AF143564 AF143565 AF143566 AF143567 AF143568 AF143569 AF143570 AF143571 AF143572 AF143573 AK135731 AY196361 AY196362 AY329484 AY329485 AY329486 AY329487 AY329488 AY329489 AY329490 AY329491 BC053384

GenPept

AAD51762 AAF64393 AAH53384 AAO52697 AAO52698 AAQ94607 AAQ94608 AAQ94609 AAQ94610 AAQ94611 AAQ94612 AAQ94613 AAQ94614 BAE22633

RNA Seq Atlas

23968