Mus musculus Gene: Odf2
Summary
InnateDB Gene IDBG-154645.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Odf2
Gene Name outer dense fiber of sperm tails 2
Synonyms AI848335; MMTEST29
Species Mus musculus
Ensembl Gene ENSMUSG00000026790
Encoded Proteins
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136811:
The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010]
The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as \'Cenexins\', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:29889221-29931746
Strand Forward strand
Band B
Transcripts
ENSMUST00000046571 ENSMUSP00000049272
ENSMUST00000028128 ENSMUSP00000028128
ENSMUST00000113767 ENSMUSP00000109396
ENSMUST00000113765 ENSMUSP00000109394
ENSMUST00000113764 ENSMUSP00000109393
ENSMUST00000113763 ENSMUSP00000109392
ENSMUST00000113762 ENSMUSP00000109391
ENSMUST00000113759 ENSMUSP00000109388
ENSMUST00000113757 ENSMUSP00000109386
ENSMUST00000113756 ENSMUSP00000109385
ENSMUST00000113755 ENSMUSP00000109384
ENSMUST00000123335 ENSMUSP00000121207
ENSMUST00000148883
ENSMUST00000126103
ENSMUST00000133233 ENSMUSP00000117628
ENSMUST00000153216
ENSMUST00000137558 ENSMUSP00000117887
ENSMUST00000150827
ENSMUST00000130899
ENSMUST00000129960
ENSMUST00000152932
ENSMUST00000131165
ENSMUST00000152503
ENSMUST00000152026
ENSMUST00000184845 ENSMUSP00000139390
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007286 spermatid development
Cellular Component
GO:0000922 spindle pole
GO:0001520 outer dense fiber
GO:0005634 nucleus
GO:0005813 centrosome
GO:0005814 centriole
GO:0005874 microtubule
GO:0005929 cilium
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Recruitment of mitotic centrosome proteins and complexes pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Loss of Nlp from mitotic centrosomes pathway
Cell Cycle pathway
Mitotic G2-G2/M phases pathway
Loss of proteins required for interphase microtubule organization√?¬†from the centrosome pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Centrosome maturation pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Regulation of PLK1 Activity at G2/M Transition pathway
Loss of Nlp from mitotic centrosomes pathway
Loss of proteins required for interphase microtubule organization√?¬†from the centrosome pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Cell Cycle pathway
Centrosome maturation pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID NCI
PLK1 signaling events
Cross-References
SwissProt
TrEMBL A3KGV9 Q8CH89
UniProt Splice Variant
Entrez Gene 18286
UniGene Mm.330116 Mm.474899
RefSeq NM_001113213 NM_001113214 NM_001177659 NM_001177661 NM_013615
OMIM
CCDS CCDS15861 CCDS50554 CCDS50555 CCDS50556 CCDS50557
HPRD
IMGT
MGI ID MGI:1098824
MGI Symbol Odf2
EMBL AB097861 AL928926
GenPept BAC44900
RNA Seq Atlas 18286