InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dmrt1

Summary

InnateDB Gene

IDBG-155403.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dmrt1

Gene Name

doublesex and mab-3 related transcription factor 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024837

Encoded Proteins

IDBP-155405

doublesex and mab-3 related transcription factor 1

IDBP-155407

doublesex and mab-3 related transcription factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137090:
This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:25505618-25604329

Strand

Forward strand

Band

Transcripts

ENSMUST00000025755	ENSMUSP00000025755
ENSMUST00000087525	ENSMUSP00000084803
ENSMUST00000160814

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000902	cell morphogenesis
GO:0002176	male germ cell proliferation
GO:0003006	developmental process involved in reproduction
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007283	spermatogenesis
GO:0008354	germ cell migration
GO:0008584	male gonad development
GO:0030238	male sex determination
GO:0035556	intracellular signal transduction
GO:0045835	negative regulation of meiosis
GO:0045840	positive regulation of mitosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046661	male sex differentiation
GO:0048599	oocyte development
GO:0060008	Sertoli cell differentiation
GO:0060009	Sertoli cell development
GO:0060903	positive regulation of meiosis I
GO:1900107	regulation of nodal signaling pathway
GO:2000020	positive regulation of male gonad development

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000137090

View Gene Order

ENSBTAG00000033352

Not yet available

Cross-References

SwissProt

Q9QZ59

TrEMBL

Q6Y950

UniProt Splice Variant

Entrez Gene

50796

UniGene

Mm.391208

RefSeq

NM_015826

OMIM

CCDS

CCDS29717

HPRD

IMGT

MGI ID

MGI:1354733

MGI Symbol

Dmrt1

EMBL

AC132140 AF192561 AF202778 AL133300 AY169785 AY169786 AY169787 AY169788 AY943925 BC125474 CH466534 DQ530630

GenPept

AAF05764 AAF12826 AAI25475 AAO41733 AAO41734 AAO41735 AAO41736 AAY20941 ABF83854 CAB62040 EDL41631

RNA Seq Atlas

50796