Homo sapiens Gene: DMRT1
Summary
InnateDB Gene IDBG-43947.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DMRT1
Gene Name doublesex and mab-3 related transcription factor 1
Synonyms CT154; DMT1;
Species Homo sapiens
Ensembl Gene ENSG00000137090
Encoded Proteins
doublesex and mab-3 related transcription factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:841690-969090
Strand Forward strand
Band p24.3
Transcripts
ENST00000382276 ENSP00000371711
ENST00000569227 ENSP00000454701
ENST00000564322
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000902 cell morphogenesis
GO:0002176 male germ cell proliferation
GO:0003006 developmental process involved in reproduction
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007283 spermatogenesis
GO:0007530 sex determination
GO:0008354 germ cell migration
GO:0008584 male gonad development
GO:0030238 male sex determination
GO:0035556 intracellular signal transduction
GO:0045835 negative regulation of meiosis
GO:0045840 positive regulation of mitosis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046661 male sex differentiation
GO:0048599 oocyte development
GO:0060008 Sertoli cell differentiation
GO:0060009 Sertoli cell development
GO:0060903 positive regulation of meiosis I
GO:1900107 regulation of nodal signaling pathway
GO:2000020 positive regulation of male gonad development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.98586
RefSeq NM_021951 XM_006716732
HUGO
OMIM
CCDS CCDS6442
HPRD 03885
IMGT
EMBL
GenPept
RNA Seq Atlas