InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DMRT1

Summary

InnateDB Gene

IDBG-631673.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DMRT1

Gene Name

doublesex- and mab-3-related transcription factor 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000033352

Encoded Proteins

IDBP-683226

doublesex and mab-3 related transcription factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137090:
This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:43916605-43972570

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000023667

ENSBTAP00000023667

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000902	cell morphogenesis
GO:0002176	male germ cell proliferation
GO:0003006	developmental process involved in reproduction
GO:0006355	regulation of transcription, DNA-templated
GO:0007283	spermatogenesis
GO:0008354	germ cell migration
GO:0008584	male gonad development
GO:0030238	male sex determination
GO:0045835	negative regulation of meiosis
GO:0045840	positive regulation of mitosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046661	male sex differentiation
GO:0048599	oocyte development
GO:0060008	Sertoli cell differentiation
GO:0060009	Sertoli cell development
GO:0060903	positive regulation of meiosis I
GO:1900107	regulation of nodal signaling pathway
GO:2000020	positive regulation of male gonad development

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000137090

View Gene Order

ENSMUSG00000024837

View Gene Order

Cross-References

SwissProt

TrEMBL

H9KUV0

UniProt Splice Variant

Entrez Gene

616245

UniGene

Bt.50653

RefSeq

NM_001078060

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02022773 DAAA02022774 DAAA02022775 DAAA02022776

GenPept

RNA Seq Atlas

616245