Mus musculus Gene: Cd8a
Summary
InnateDB Gene IDBG-155582.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd8a
Gene Name CD8 antigen, alpha chain
Synonyms BB154331; Ly-2; Ly-35; Ly-B; Lyt-2;
Species Mus musculus
Ensembl Gene ENSMUSG00000053977
Encoded Proteins
CD8 antigen, alpha chain
CD8 antigen, alpha chain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Cd8a-positive dendritic cells play a critical role in cross-presentation of antigens during intracellular pathogen infections, specifically by activating an innate immune response through Il12 production.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] CD8A-positive dendritic cells play a critical role in cross-presentation of antigens during intracellular pathogen infections, specifically by activating an innate immune response through IL12 production. (Demonstrated in murine model)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153563:
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:71373427-71379171
Strand Forward strand
Band C1
Transcripts
ENSMUST00000066747 ENSMUSP00000068123
ENSMUST00000172321 ENSMUSP00000131873
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0002456 T cell mediated immunity
GO:0007166 cell surface receptor signaling pathway
GO:0042110 T cell activation
GO:0045065 cytotoxic T cell differentiation
GO:0045087 innate immune response (InnateDB)
GO:0050850 positive regulation of calcium-mediated signaling
GO:0051607 defense response to virus
Cellular Component
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Immune System pathway
Adaptive Immune System pathway
KEGG
Cell adhesion molecules (CAMs) pathway
Antigen processing and presentation pathway
Hematopoietic cell lineage pathway
T cell receptor signaling pathway pathway
Primary immunodeficiency pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TCR pathway
REACTOME
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Adaptive Immune System pathway
Immune System pathway
KEGG
Cell adhesion molecules (CAMs) pathway
Antigen processing and presentation pathway
Hematopoietic cell lineage pathway
T cell receptor signaling pathway pathway
Primary immunodeficiency pathway
INOH
PID BIOCARTA
PID NCI
TCR signaling in na´ve CD8+ T cells
Downstream signaling in na´ve CD8+ T cells
IL12-mediated signaling events
Cross-References
SwissProt P01731
TrEMBL Q3UUV7 Q8K2M2
UniProt Splice Variant
Entrez Gene 12525
UniGene Mm.1858
RefSeq NM_001081110 XM_006505464 NM_009857 XM_006505465
OMIM
CCDS CCDS39507 CCDS51806
HPRD
IMGT
MGI ID MGI:88346
MGI Symbol Cd8a
EMBL AK137937 BC030679 M12052 M12819 M12825 M12975 M12976 M12977 M16981 M22064 Y00157
GenPept AAA39475 AAA39476 AAA39477 AAA39478 AAA39665 AAH30679 BAE23516 CAA68352
RNA Seq Atlas 12525