Bos taurus Gene: CD8A
Summary
InnateDB Gene IDBG-634911.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD8A
Gene Name T-cell surface glycoprotein CD8 alpha chain precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021141
Encoded Proteins
T-cell surface glycoprotein CD8 alpha chain precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] CD8A-positive dendritic cells play a critical role in cross-presentation of antigens during intracellular pathogen infections, specifically by activating an innate immune response through IL12 production. (Demonstrated in murine model)
[Mus musculus] Cd8a-positive dendritic cells play a critical role in cross-presentation of antigens during intracellular pathogen infections, specifically by activating an innate immune response through Il12 production.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153563:
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:47988169-47995400
Strand Forward strand
Band
Transcripts
ENSBTAT00000028175 ENSBTAP00000028175
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0002456 T cell mediated immunity
GO:0007166 cell surface receptor signaling pathway
GO:0045065 cytotoxic T cell differentiation
GO:0050850 positive regulation of calcium-mediated signaling
GO:0051607 defense response to virus
Cellular Component
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
TCR pathway
REACTOME
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Adaptive Immune System pathway
Immune System pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Immune System pathway
Adaptive Immune System pathway
KEGG
Hematopoietic cell lineage pathway
Cell adhesion molecules (CAMs) pathway
Antigen processing and presentation pathway
T cell receptor signaling pathway pathway
Primary immunodeficiency pathway
Cell adhesion molecules (CAMs) pathway
Hematopoietic cell lineage pathway
Antigen processing and presentation pathway
T cell receptor signaling pathway pathway
Primary immunodeficiency pathway
INOH
PID NCI
TCR signaling in na´ve CD8+ T cells
Downstream signaling in na´ve CD8+ T cells
IL12-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.50
RefSeq NM_174015
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas