Version 5.4
Homo sapiens Gene: CD8A
Summary
InnateDB Gene IDBG-59987.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD8A
Gene Name CD8a molecule
Synonyms CD8; Leu2; MAL; p32
Species Homo sapiens
Ensembl Gene ENSG00000153563
Encoded Proteins
IDBP-59989
CD8a molecule
IDBP-59991
CD8a molecule
IDBP-295331
CD8a molecule
IDBP-295305
CD8a molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21867928
CD8A-positive dendritic cells play a critical role in cross-presentation of antigens during intracellular pathogen infections, specifically by activating an innate immune response through IL12 production. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
PMID 21867928
[Mus musculus] Cd8a-positive dendritic cells play a critical role in cross-presentation of antigens during intracellular pathogen infections, specifically by activating an innate immune response through Il12 production.
Entrez Gene
Summary The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:86784610-86808396
Strand Reverse strand
Band p11.2
Transcripts
ENST00000283635 ENSP00000283635
ENST00000352580 ENSP00000321631
ENST00000409511 ENSP00000386559
ENST00000409781 ENSP00000387314
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015026 coreceptor activity
GO:0019901 protein kinase binding
GO:0042288 MHC class I protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0002456 T cell mediated immunity
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0019882 antigen processing and presentation
GO:0042110 T cell activation
GO:0045065 cytotoxic T cell differentiation
GO:0045087 innate immune response (InnateDB)
GO:0050776 regulation of immune response
GO:0050850 positive regulation of calcium-mediated signaling
GO:0051607 defense response to virus
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0042101 T cell receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000053977
View Gene Order
ENSBTAG00000021141
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04612
Antigen processing and presentation pathway
hsa04660
T cell receptor signaling pathway pathway
hsa05340
Primary immunodeficiency pathway
INOH
PID NCI
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
il12_2pathway
IL12-mediated signaling events
Cross-References
SwissProt P01732
TrEMBL B8ZZZ4
UniProt Splice Variant
Entrez Gene 925
UniGene Hs.85258
RefSeq NM_001145873 NM_001768 NM_171827
HUGO HGNC:1706
OMIM 186910
CCDS CCDS1992 CCDS1993
HPRD
IMGT
EMBL AC064848 AC112696 AK300089 CH471053 M12824 M12828 M26313 M26314 M26315 M27161
GenPept AAA59674 AAA61133 AAA79217 AAA79218 AAB04637 AAX88864 BAG61892 EAW99438 EAW99439 EAW99440 EAW99441
RNA Seq Atlas 925

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca