InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Arhgef1

Summary

InnateDB Gene

IDBG-155851.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arhgef1

Gene Name

Rho guanine nucleotide exchange factor (GEF) 1

Synonyms

Lbcl2; Lsc

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040940

Encoded Proteins

IDBP-155853

Rho guanine nucleotide exchange factor (GEF) 1

IDBP-155855

Rho guanine nucleotide exchange factor (GEF) 1

IDBP-401314

Rho guanine nucleotide exchange factor (GEF) 1

IDBP-401313

Rho guanine nucleotide exchange factor (GEF) 1

IDBP-533577

Rho guanine nucleotide exchange factor (GEF) 1

IDBP-539594

Rho guanine nucleotide exchange factor (GEF) 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000076928:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:24902912-24926592

Strand

Forward strand

Band

Transcripts

ENSMUST00000098683	ENSMUSP00000096280
ENSMUST00000047873	ENSMUSP00000046469
ENSMUST00000117796	ENSMUSP00000113771
ENSMUST00000117419	ENSMUSP00000113366
ENSMUST00000129383
ENSMUST00000127761
ENSMUST00000145783
ENSMUST00000151121	ENSMUSP00000114388
ENSMUST00000144714
ENSMUST00000132751	ENSMUSP00000117008
ENSMUST00000129928
ENSMUST00000126484
ENSMUST00000126918
ENSMUST00000132786

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity