Mus musculus Gene: Arhgef1
Summary
InnateDB Gene IDBG-155851.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgef1
Gene Name Rho guanine nucleotide exchange factor (GEF) 1
Synonyms Lbcl2; Lsc;
Species Mus musculus
Ensembl Gene ENSMUSG00000040940
Encoded Proteins
Rho guanine nucleotide exchange factor (GEF) 1
Rho guanine nucleotide exchange factor (GEF) 1
Rho guanine nucleotide exchange factor (GEF) 1
Rho guanine nucleotide exchange factor (GEF) 1
Rho guanine nucleotide exchange factor (GEF) 1
Rho guanine nucleotide exchange factor (GEF) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000076928:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:24902912-24926592
Strand Forward strand
Band A3
Transcripts
ENSMUST00000098683 ENSMUSP00000096280
ENSMUST00000047873 ENSMUSP00000046469
ENSMUST00000117796 ENSMUSP00000113771
ENSMUST00000117419 ENSMUSP00000113366
ENSMUST00000129383
ENSMUST00000127761
ENSMUST00000145783
ENSMUST00000151121 ENSMUSP00000114388
ENSMUST00000144714
ENSMUST00000132751 ENSMUSP00000117008
ENSMUST00000129928
ENSMUST00000126484
ENSMUST00000126918
ENSMUST00000132786
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
GPCR downstream signaling pathway
p75NTR regulates axonogenesis pathway
Signaling by GPCR pathway
Axonal growth inhibition (RHOA activation) pathway
G alpha (12/13) signalling events pathway
Signalling by NGF pathway
Signal Transduction pathway
p75 NTR receptor-mediated signalling pathway
KEGG
Vascular smooth muscle contraction pathway
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TNFalpha pathway
REACTOME
G alpha (12/13) signalling events pathway
Signalling by NGF pathway
p75NTR regulates axonogenesis pathway
Signaling by GPCR pathway
p75 NTR receptor-mediated signalling pathway
Axonal growth inhibition (RHOA activation) pathway
Signal Transduction pathway
GPCR downstream signaling pathway
KEGG
Vascular smooth muscle contraction pathway
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
Rho cell motility signaling pathway [Biocarta view]
Rac1 cell motility signaling pathway [Biocarta view]
Pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase [Biocarta view]
PID NCI
Thromboxane A2 receptor signaling
LPA receptor mediated events
PAR1-mediated thrombin signaling events
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL D3YVJ9 E9PUF7
UniProt Splice Variant
Entrez Gene 16801
UniGene Mm.3181 Mm.407747
RefSeq NM_001130151 XM_006539564 NM_001130150 NM_001130152 NM_001130153 NM_008488 XM_006539565
OMIM
CCDS CCDS52140 CCDS52141 CCDS52142
HPRD
IMGT
MGI ID MGI:1353510
MGI Symbol Arhgef1
EMBL AC161441
GenPept
RNA Seq Atlas 16801