Bos taurus Gene: ARHGEF1
Summary
InnateDB Gene IDBG-638817.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF1
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018912
Encoded Proteins
Rho guanine nucleotide exchange factor (GEF) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000076928:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:51658123-51678112
Strand Reverse strand
Band
Transcripts
ENSBTAT00000025175 ENSBTAP00000025175
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0038032 termination of G-protein coupled receptor signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathway Predictions based on Human Orthology Data
NETPATH
TNFalpha pathway
REACTOME
G alpha (12/13) signalling events pathway
Signalling by NGF pathway
p75NTR regulates axonogenesis pathway
Signaling by GPCR pathway
p75 NTR receptor-mediated signalling pathway
Axonal growth inhibition (RHOA activation) pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR downstream signaling pathway
p75NTR regulates axonogenesis pathway
Signaling by GPCR pathway
Axonal growth inhibition (RHOA activation) pathway
G alpha (12/13) signalling events pathway
Signalling by NGF pathway
Signal Transduction pathway
p75 NTR receptor-mediated signalling pathway
KEGG
Vascular smooth muscle contraction pathway
Regulation of actin cytoskeleton pathway
Vascular smooth muscle contraction pathway
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
Rho cell motility signaling pathway [Biocarta view]
Rac1 cell motility signaling pathway [Biocarta view]
Pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase [Biocarta view]
PID NCI
Thromboxane A2 receptor signaling
LPA receptor mediated events
PAR1-mediated thrombin signaling events
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL E1BG38
UniProt Splice Variant
Entrez Gene 513377
UniGene Bt.21775
RefSeq XM_002695075 XM_591046
HUGO HGNC:681
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02047237 DAAA02047238
GenPept
RNA Seq Atlas 513377
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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