InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ptpn2

Summary

InnateDB Gene

IDBG-155927.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptpn2

Gene Name

protein tyrosine phosphatase, non-receptor type 2

Synonyms

AI325124; Ptpt; TC-PTP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024539

Encoded Proteins

IDBP-155929

protein tyrosine phosphatase, non-receptor type 2

IDBP-401287

protein tyrosine phosphatase, non-receptor type 2

IDBP-401286

protein tyrosine phosphatase, non-receptor type 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 14600148

[Homo sapiens] PTPN2 pays a novel role in the regulation of type 1 interferon-stimulated gene expression in cells previously desensitized to Type 1 interferons.

PMID 11773439

[Homo sapiens] PTPN2 is a nuclear protein tyrosine phosphatase, a potential negative regulator of the PRL-mediated signalling pathway.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175354:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:67665511-67724595

Strand

Reverse strand

Band

Transcripts

ENSMUST00000025420	ENSMUSP00000025420
ENSMUST00000120934	ENSMUSP00000113182
ENSMUST00000122412	ENSMUSP00000112675
ENSMUST00000128169

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0019901	protein kinase binding
GO:0019905	syntaxin binding
GO:0030971	receptor tyrosine kinase binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0008285	negative regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010888	negative regulation of lipid storage
GO:0016311	dephosphorylation
GO:0030183	B cell differentiation
GO:0030217	T cell differentiation
GO:0030218	erythrocyte differentiation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0042512	negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein
GO:0042527	negative regulation of tyrosine phosphorylation of Stat6 protein
GO:0042593	glucose homeostasis
GO:0045650	negative regulation of macrophage differentiation
GO:0045722	positive regulation of gluconeogenesis
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0050728	negative regulation of inflammatory response
GO:0050860	negative regulation of T cell receptor signaling pathway
GO:0050922	negative regulation of chemotaxis
GO:0060336	negative regulation of interferon-gamma-mediated signaling pathway
GO:0060339	negative regulation of type I interferon-mediated signaling pathway
GO:0070104	negative regulation of interleukin-6-mediated signaling pathway
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway
GO:1902206	negative regulation of interleukin-2-mediated signaling pathway
GO:1902212	negative regulation of prolactin signaling pathway
GO:1902215	negative regulation of interleukin-4-mediated signaling pathway
GO:1902227	negative regulation of macrophage colony-stimulating factor signaling pathway
GO:1902233	negative regulation of positive thymic T cell selection
GO:2000587	negative regulation of platelet-derived growth factor receptor-beta signaling pathway