Mus musculus Gene: Ptpn2
Summary
InnateDB Gene IDBG-155927.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptpn2
Gene Name protein tyrosine phosphatase, non-receptor type 2
Synonyms AI325124; Ptpt; TC-PTP;
Species Mus musculus
Ensembl Gene ENSMUSG00000024539
Encoded Proteins
protein tyrosine phosphatase, non-receptor type 2
protein tyrosine phosphatase, non-receptor type 2
protein tyrosine phosphatase, non-receptor type 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] PTPN2 pays a novel role in the regulation of type 1 interferon-stimulated gene expression in cells previously desensitized to Type 1 interferons.
[Homo sapiens] PTPN2 is a nuclear protein tyrosine phosphatase, a potential negative regulator of the PRL-mediated signalling pathway.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175354:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:67665511-67724595
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000025420 ENSMUSP00000025420
ENSMUST00000120934 ENSMUSP00000113182
ENSMUST00000122412 ENSMUSP00000112675
ENSMUST00000128169
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0019901 protein kinase binding
GO:0019905 syntaxin binding
GO:0030971 receptor tyrosine kinase binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0008285 negative regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010888 negative regulation of lipid storage
GO:0016311 dephosphorylation
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030218 erythrocyte differentiation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042512 negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0042524 negative regulation of tyrosine phosphorylation of Stat5 protein
GO:0042527 negative regulation of tyrosine phosphorylation of Stat6 protein
GO:0042593 glucose homeostasis
GO:0045650 negative regulation of macrophage differentiation
GO:0045722 positive regulation of gluconeogenesis
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0050728 negative regulation of inflammatory response
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050922 negative regulation of chemotaxis
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0070104 negative regulation of interleukin-6-mediated signaling pathway
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway
GO:1902206 negative regulation of interleukin-2-mediated signaling pathway
GO:1902212 negative regulation of prolactin signaling pathway
GO:1902215 negative regulation of interleukin-4-mediated signaling pathway
GO:1902227 negative regulation of macrophage colony-stimulating factor signaling pathway
GO:1902233 negative regulation of positive thymic T cell selection
GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Cytokine Signaling in Immune system pathway
Immune System pathway
Regulation of IFNG signaling pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Signaling events mediated by TCPTP
Signaling events mediated by VEGFR1 and VEGFR2
PDGFR-beta signaling pathway
IFN-gamma pathway
Cross-References
SwissProt Q06180
TrEMBL D3Z6W2
UniProt Splice Variant
Entrez Gene 19255
UniGene Mm.260433 Mm.421946
RefSeq NM_001127177 NM_008977 XM_006525723
OMIM
CCDS CCDS37851 CCDS50311
HPRD
IMGT
MGI ID MGI:97806
MGI Symbol Ptpn2
EMBL AC108434 AK076072 AK132013 BC008269 M81477 S52655
GenPept AAA37446 AAB25035 AAH08269 BAC36163 BAE20939
RNA Seq Atlas 19255