Version 5.4
Mus musculus Gene: Vldlr
Summary
InnateDB Gene IDBG-155959.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vldlr
Gene Name very low density lipoprotein receptor
Synonyms AA408956; AI451093; AW047288
Species Mus musculus
Ensembl Gene ENSMUSG00000024924
Encoded Proteins
IDBP-155961
very low density lipoprotein receptor
IDBP-155963
very low density lipoprotein receptor
IDBP-620953
very low density lipoprotein receptor
IDBP-620978
very low density lipoprotein receptor
IDBP-620991
very low density lipoprotein receptor
IDBP-620992
very low density lipoprotein receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21642441
Vldlr is exploited by rhinovirus for viral entry. Vldlr protein levels are negatively regulated by IFN/RIG-I signalling via MIR23B. (Demonstrated in human)
InnateDB Annotation from Orthologs
Summary
PMID 21642441
[Homo sapiens] VLDLR is exploited by rhinovirus for viral entry. VLDLR protein levels are negatively regulated by IFN/RIG-I signalling via MIR23B.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147852:
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:27216484-27254231
Strand Forward strand
Band C1
Transcripts
ENSMUST00000047645 ENSMUSP00000049145
ENSMUST00000025866 ENSMUSP00000025866
ENSMUST00000164509
ENSMUST00000164746 ENSMUSP00000128193
ENSMUST00000172302 ENSMUSP00000126730
ENSMUST00000163729
ENSMUST00000167487 ENSMUSP00000127329
ENSMUST00000165761 ENSMUSP00000130382
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0030229 very-low-density lipoprotein particle receptor activity
GO:0034189 very-low-density lipoprotein particle binding
GO:0034437 glycoprotein transporter activity
GO:0038025 reelin receptor activity
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006869 lipid transport
GO:0006898 receptor-mediated endocytosis
GO:0008203 cholesterol metabolic process
GO:0021517 ventral spinal cord development
GO:0034436 glycoprotein transport
GO:0034447 very-low-density lipoprotein particle clearance
GO:0038026 reelin-mediated signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0045860 positive regulation of protein kinase activity
GO:1900006 positive regulation of dendrite development
Cellular Component
GO:0005615 extracellular space
GO:0005905 coated pit
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0034361 very-low-density lipoprotein particle
GO:0043235 receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000147852
View Gene Order
ENSBTAG00000018517
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
reelinpathway
Reelin signaling pathway
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
lis1pathway
Lissencephaly gene (LIS1) in neuronal migration and development
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.405973 Mm.4141 Mm.488198
RefSeq NM_001161420 NM_013703 XM_006526917 XM_006526918 XM_006526919 XM_006526920
OMIM
CCDS CCDS29721 CCDS50411
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca