InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: VLDLR

Summary

InnateDB Gene

IDBG-631615.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VLDLR

Gene Name

very low-density lipoprotein receptor precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018517

Encoded Proteins

IDBP-683171

very low-density lipoprotein receptor precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21642441

[Homo sapiens] VLDLR is exploited by rhinovirus for viral entry. VLDLR protein levels are negatively regulated by IFN/RIG-I signalling via MIR23B.

PMID 21642441

[Mus musculus] Vldlr is exploited by rhinovirus for viral entry. Vldlr protein levels are negatively regulated by IFN/RIG-I signalling via MIR23B. (Demonstrated in human)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147852:
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:42109679-42141155

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000047258

ENSBTAP00000044478

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0030229	very-low-density lipoprotein particle receptor activity
GO:0034189	very-low-density lipoprotein particle binding
GO:0034437	glycoprotein transporter activity
GO:0038025	reelin receptor activity
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006898	receptor-mediated endocytosis
GO:0021517	ventral spinal cord development
GO:0034436	glycoprotein transport
GO:0034447	very-low-density lipoprotein particle clearance
GO:0038026	reelin-mediated signaling pathway
GO:0045860	positive regulation of protein kinase activity
GO:1900006	positive regulation of dendrite development

Cellular Component

GO:0005615	extracellular space
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000147852

View Gene Order

ENSMUSG00000024924

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

reelinpathway

Reelin signaling pathway

upa_upar_pathway

Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

lis1pathway

Lissencephaly gene (LIS1) in neuronal migration and development

Cross-References

SwissProt

TrEMBL

F1MIQ2

UniProt Splice Variant

Entrez Gene

282123

UniGene

Bt.5484

RefSeq

NM_174489

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02022737

GenPept

RNA Seq Atlas

282123