Mus musculus Gene: Parp2
Summary
InnateDB Gene IDBG-156335.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Parp2
Gene Name poly (ADP-ribose) polymerase family, member 2
Synonyms Adprt2; Adprtl2; ARTD2; Aspartl2; C78626; PARP-2;
Species Mus musculus
Ensembl Gene ENSMUSG00000036023
Encoded Proteins
poly (ADP-ribose) polymerase family, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129484:
This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:50807946-50821300
Strand Forward strand
Band C1
Transcripts
ENSMUST00000036126 ENSMUSP00000048877
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005515 protein binding
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006471 protein ADP-ribosylation
GO:0097191 extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Base excision repair pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Base excision repair pathway
INOH
PID BIOCARTA
PID NCI
Regulation of Telomerase
Cross-References
SwissProt O88554
TrEMBL
UniProt Splice Variant
Entrez Gene 11546
UniGene
RefSeq NM_009632 XM_006518442
OMIM
CCDS CCDS27025
HPRD
IMGT
MGI ID MGI:1341112
MGI Symbol Parp2
EMBL AF072521 AF191547 AJ007780 BC062150
GenPept AAC25415 AAH62150 AAK13253 CAA07679
RNA Seq Atlas 11546