Mus musculus Gene: Pnpt1
Summary
InnateDB Gene IDBG-156498.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pnpt1
Gene Name polyribonucleotide nucleotidyltransferase 1
Synonyms 1200003F12Rik; Old35; PNPase; Pnptl1;
Species Mus musculus
Ensembl Gene ENSMUSG00000020464
Encoded Proteins
polyribonucleotide nucleotidyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138035:
The protein encoded by this gene belongs to the evolutionary conserved polynucleotide phosphorylase family comprised of phosphate dependent 3'-to-5' exoribonucleases implicated in RNA processing and degradation. This enzyme is predominantly localized in the mitochondrial intermembrane space and is involved in import of RNA to mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency-13 and autosomal recessive nonsyndromic deafness-70. Related pseudogenes are found on chromosomes 3 and 7. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:29130744-29161828
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000020756 ENSMUSP00000020756
ENSMUST00000154924
ENSMUST00000148173
ENSMUST00000131527
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000175 3'-5'-exoribonuclease activity
GO:0003723 RNA binding
GO:0004654 polyribonucleotide nucleotidyltransferase activity
GO:0005515 protein binding
GO:0008266 poly(U) RNA binding
GO:0034046 poly(G) binding
GO:0035198 miRNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000957 mitochondrial RNA catabolic process
GO:0000958 mitochondrial mRNA catabolic process
GO:0000962 positive regulation of mitochondrial RNA catabolic process
GO:0000964 mitochondrial RNA 5'-end processing
GO:0000965 mitochondrial RNA 3'-end processing
GO:0006396 RNA processing
GO:0006401 RNA catabolic process
GO:0006402 mRNA catabolic process
GO:0034599 cellular response to oxidative stress
GO:0035458 cellular response to interferon-beta
GO:0035927 RNA import into mitochondrion
GO:0035928 rRNA import into mitochondrion
GO:0043457 regulation of cellular respiration
GO:0043631 RNA polyadenylation
GO:0045926 negative regulation of growth
GO:0051260 protein homooligomerization
GO:0061014 positive regulation of mRNA catabolic process
GO:0070207 protein homotrimerization
GO:0070584 mitochondrion morphogenesis
GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process
GO:0071850 mitotic cell cycle arrest
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:0097222 mitochondrial mRNA polyadenylation
GO:2000627 positive regulation of miRNA catabolic process
GO:2000772 regulation of cellular senescence
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005886 plasma membrane
GO:0045025 mitochondrial degradosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Purine metabolism pathway
Pyrimidine metabolism pathway
RNA degradation pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Purine metabolism pathway
Pyrimidine metabolism pathway
RNA degradation pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8K1R3
TrEMBL
UniProt Splice Variant
Entrez Gene 71701
UniGene Mm.211131
RefSeq NM_027869
OMIM
CCDS CCDS24490
HPRD
IMGT
MGI ID MGI:1918951
MGI Symbol Pnpt1
EMBL AF465249 AJ507387 AK004563 AK149419 BC027228 BC049283 BC055826 BX000351
GenPept AAH27228 AAH49283 AAH55826 AAO33354 BAB23374 BAE28862 CAD45436 CAI25081
RNA Seq Atlas 71701