InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Trim32

Summary

InnateDB Gene

IDBG-156706.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim32

Gene Name

tripartite motif-containing 32

Synonyms

1810045E12Rik; 3f3; BBS11; Zfp117

Species

Mus musculus

Ensembl Gene

ENSMUSG00000051675

Encoded Proteins

IDBP-156708

tripartite motif-containing 32

IDBP-266821

tripartite motif-containing 32

IDBP-534818

tripartite motif-containing 32

IDBP-539749

tripartite motif-containing 32

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22745133

Trim32 targets Tmem173 for ubiquitination and enhances the induction of Ifnb against RNA and DNA viruses. (Demonstrated in human)

InnateDB Annotation from Orthologs

Summary

PMID 22745133

[Homo sapiens] TRIM32 targets TMEM173 for ubiquitination and enhances the induction of IFNB against RNA and DNA viruses.

PMID 23438823

[Homo sapiens] TRIM32 was identified in a systematic screen for positive regulators of innate immune responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119401:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:65604986-65616238

Strand

Forward strand

Band

Transcripts

ENSMUST00000050850	ENSMUSP00000062277
ENSMUST00000107366	ENSMUSP00000102989
ENSMUST00000155978	ENSMUSP00000119579
ENSMUST00000156922	ENSMUSP00000121949

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0017022	myosin binding
GO:0031369	translation initiation factor binding
GO:0043130	ubiquitin binding
GO:0043621	protein self-association
GO:0046872	metal ion binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0009411	response to UV
GO:0016567	protein ubiquitination
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0032897	negative regulation of viral transcription
GO:0034612	response to tumor necrosis factor
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0045444	fat cell differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045732	positive regulation of protein catabolic process
GO:0045787	positive regulation of cell cycle
GO:0045862	positive regulation of proteolysis
GO:0048147	negative regulation of fibroblast proliferation
GO:0050769	positive regulation of neurogenesis
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:1902173	negative regulation of keratinocyte apoptotic process
GO:1902187	negative regulation of viral release from host cell
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000147	positive regulation of cell motility