InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TRIM32

Summary

InnateDB Gene

IDBG-638754.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM32

Gene Name

E3 ubiquitin-protein ligase TRIM32

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017155

Encoded Proteins

IDBP-690847

E3 ubiquitin-protein ligase TRIM32

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 22745133

[Homo sapiens] TRIM32 targets TMEM173 for ubiquitination and enhances the induction of IFNB against RNA and DNA viruses.

PMID 23438823

[Homo sapiens] TRIM32 was identified in a systematic screen for positive regulators of innate immune responses.

PMID 22745133

[Mus musculus] Trim32 targets Tmem173 for ubiquitination and enhances the induction of Ifnb against RNA and DNA viruses. (Demonstrated in human)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119401:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:107645159-107656813

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022801

ENSBTAP00000022801

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0017022	myosin binding
GO:0031369	translation initiation factor binding
GO:0043130	ubiquitin binding
GO:0043621	protein self-association
GO:0046872	metal ion binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0009411	response to UV
GO:0016567	protein ubiquitination
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0032897	negative regulation of viral transcription
GO:0034612	response to tumor necrosis factor
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045444	fat cell differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045732	positive regulation of protein catabolic process
GO:0045787	positive regulation of cell cycle
GO:0045862	positive regulation of proteolysis
GO:0048147	negative regulation of fibroblast proliferation
GO:0050769	positive regulation of neurogenesis
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:1902187	negative regulation of viral release from host cell
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000147	positive regulation of cell motility