Version 5.4
Homo sapiens Gene: TRIM32
Summary
InnateDB Gene IDBG-82716.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM32
Gene Name tripartite motif containing 32
Synonyms BBS11; HT2A; LGMD2H; TATIP
Species Homo sapiens
Ensembl Gene ENSG00000119401
Encoded Proteins
IDBP-82718
tripartite motif containing 32
IDBP-378852
tripartite motif containing 32
IDBP-378861
tripartite motif containing 32
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22745133
TRIM32 targets TMEM173 for ubiquitination and enhances the induction of IFNB against RNA and DNA viruses.
PMID 23438823
TRIM32 was identified in a systematic screen for positive regulators of innate immune responses.
InnateDB Annotation from Orthologs
Summary
PMID 22745133
[Mus musculus] Trim32 targets Tmem173 for ubiquitination and enhances the induction of Ifnb against RNA and DNA viruses. (Demonstrated in human)
Entrez Gene
Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:116687302-116701300
Strand Forward strand
Band q33.1
Transcripts
ENST00000373983 ENSP00000363095
ENST00000450136 ENSP00000408292
ENST00000411410 ENSP00000412603
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 77 [view]
Protein-Protein 77 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0017022 myosin binding
GO:0030957 Tat protein binding
GO:0031369 translation initiation factor binding
GO:0043130 ubiquitin binding
GO:0043621 protein self-association
GO:0046872 metal ion binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0009411 response to UV
GO:0016567 protein ubiquitination
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0032479 regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0032897 negative regulation of viral transcription
GO:0034612 response to tumor necrosis factor
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0045444 fat cell differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045787 positive regulation of cell cycle
GO:0045862 positive regulation of proteolysis
GO:0048147 negative regulation of fibroblast proliferation
GO:0050769 positive regulation of neurogenesis
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:1902187 negative regulation of viral release from host cell
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000147 positive regulation of cell motility
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005863 striated muscle myosin thick filament
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051675
View Gene Order
ENSBTAG00000017155
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_6802
Innate Immune System pathway
REACT_163977
Regulation of innate immune responses to cytosolic DNA pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt Q13049
TrEMBL A0A024R843 Q5JVY0
UniProt Splice Variant
Entrez Gene 22954
UniGene Hs.591910
RefSeq NM_001099679 NM_012210 XM_005251813
HUGO HGNC:16380
OMIM 602290
CCDS CCDS6817
HPRD 03797
IMGT
EMBL AL133284 BC003154 CH471090 U18543
GenPept AAA86474 AAH03154 CAB92723 EAW87446 EAW87447
RNA Seq Atlas 22954

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca