Version 5.4
Mus musculus Gene: Brcc3
Summary
InnateDB Gene IDBG-157387.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Brcc3
Gene Name BRCA1/BRCA2-containing complex, subunit 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000031201
Encoded Proteins
IDBP-157389
BRCA1/BRCA2-containing complex, subunit 3
IDBP-252528
BRCA1/BRCA2-containing complex, subunit 3
IDBP-400896
BRCA1/BRCA2-containing complex, subunit 3
IDBP-542516
BRCA1/BRCA2-containing complex, subunit 3
IDBP-626291
BRCA1/BRCA2-containing complex, subunit 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185515:
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome X:75416628-75454001
Strand Forward strand
Band A7.3
Transcripts
ENSMUST00000033544 ENSMUSP00000033544
ENSMUST00000114074 ENSMUSP00000109708
ENSMUST00000118428 ENSMUSP00000114057
ENSMUST00000151938
ENSMUST00000133781 ENSMUSP00000123031
ENSMUST00000152228 ENSMUSP00000127772
ENSMUST00000124321
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 35 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0030234 enzyme regulator activity
GO:0031593 polyubiquitin binding
GO:0046872 metal ion binding
Biological Process
GO:0006302 double-strand break repair
GO:0006508 proteolysis
GO:0010165 response to X-ray
GO:0010212 response to ionizing radiation
GO:0031572 G2 DNA damage checkpoint
GO:0045739 positive regulation of DNA repair
GO:0050790 regulation of catalytic activity
GO:0070536 protein K63-linked deubiquitination
GO:0070537 histone H2A K63-linked deubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0000152 nuclear ubiquitin ligase complex
GO:0005634 nucleus
GO:0070531 BRCA1-A complex
GO:0070552 BRISC complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000185515
View Gene Order
ENSBTAG00000007817
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.226957 Mm.402654 Mm.416059
RefSeq NM_001166457 NM_001166459 NM_145956
OMIM
CCDS CCDS41031
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca