Bos taurus Gene: BT.58955 | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Gene | IDBG-632093.3 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | BT.58955 | ||||||||||||||||
Gene Name | lys-63-specific deubiquitinase BRCC36 | ||||||||||||||||
Synonyms | CXorf53 | ||||||||||||||||
Species | Bos taurus | ||||||||||||||||
Ensembl Gene | ENSBTAG00000007817 | ||||||||||||||||
Encoded Proteins |
lys-63-specific deubiquitinase BRCC36
lys-63-specific deubiquitinase BRCC36
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Protein Structure | |||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
Entrez Gene | |||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185515:
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011] |
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Gene Information | |||||||||||||||||
Type | Protein coding | ||||||||||||||||
Genomic Location | Chromosome X:38709695-38788194 | ||||||||||||||||
Strand | Reverse strand | ||||||||||||||||
Band | |||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Cross-References | |||||||||||||||||
SwissProt | |||||||||||||||||
TrEMBL | G3X874 G5E595 | ||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | 519513 | ||||||||||||||||
UniGene | Bt.58955 | ||||||||||||||||
RefSeq | NM_001075790 XM_005227647 XM_005227649 | ||||||||||||||||
HUGO | HGNC:24185 | ||||||||||||||||
OMIM | |||||||||||||||||
CCDS | |||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | DAAA02070022 DAAA02070023 DAAA02070024 DAAA02070025 | ||||||||||||||||
GenPept | |||||||||||||||||
RNA Seq Atlas | 519513 | ||||||||||||||||